Associations of HLA class I alleles in Japanese patients with Crohn's disease.
Associations of HLA class I alleles in Japanese patients with Crohn's disease.
复制标题
日本克罗恩病患者 HLA I 类等位基因的关联。
DOI：
10.1038/gene.2014.61
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Sasazuki T.
中科院分区：
文献类型：
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作者：
102)Oryoji D;Hisamatsu T;Tsuchiya K;Umeno J;Ueda S;Yamamoto K;Matsumoto T;Watanabe M;Hibi T;Sasazuki T.
以往的研究表明人类白细胞抗原(人类白细胞抗原)与克罗恩病(CD)的病因有关，然而，关于人类白细胞抗原I类抗原与CD之间的关系在日本鲜有报道。在这项研究中，我们对208名日本患者和384名健康对照进行了CD中HLAI类抗原的关联分析。我们发现CD与HLAA02：01(优势比OR=1.64，P=0.016)和HLAA02：07(OR=2.31，P=0.0067)之间存在新的正相关，并证实了CD与HLACW14：02(OR=2.18P=0.0021)和HLAB51：01(OR=1.7，P=0.033)之间的正相关。CD与HLAA*24：02(OR=0.6，P=0.0047)和HLAB*07：02(OR=0.38，P=0.0041)之间存在新的负相关。尽管经完全Bonferroni校正后相关性不明显，但我们认为人类白细胞抗原I类基因在控制CD的发生发展中具有双重功能，即易感性和抵抗性。
Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn’s disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A* 02: 01 (odds ratio (OR)= 1.64, P= 0.016) and HLA-A* 02: 07 (OR= 2.31, P= 0.0067) and confirmed previously reported positive associations between CD and HLA-Cw* 14: 02 (OR= 2.18, P= 0.0021) and HLA-B* 51: 01 (OR= 1.70, P= 0.033). We also identified novel negative associations between CD and HLA-A* 24: 02 (OR= 0.60, P= 0.0047) and HLA-B* 07: 02 (OR= 0.38, P= 0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.