Preparation and characterization of hydroxyapatite microspheres with hollow core and mesoporous shell
Preparation and characterization of hydroxyapatite microspheres with hollow core and mesoporous shell
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DOI：
10.4028/www.scientific.net/kem.309-311.65
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Weng, J
中科院分区：
文献类型：
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作者：
Peng, Q;Ming, L;Weng, J
采用核模板技术和溶胶-凝胶法成功制备了壳层具有可控介孔结构的中空羟基磷灰石微球。H-HAM的制造主要包括三个不同的步骤：通过将甲壳素溶液在油中乳化制备甲壳素核模板球，在甲壳素核模板表面包覆一层甲壳素/HA溶液后，通过甲壳素溶液在核中的水的帮助下的胶凝过程形成甲壳素-HA/甲壳素核壳复合球，以及通过特殊的烧结程序以除去几丁质来收获H-HAM。H-HAMs的尺寸和形状主要取决于核模板的尺寸和形貌。壳层的厚度可以通过改变初始模板粒子的含水量来控制，壳层上的介孔结构特征与壳层中甲壳素的比例和烧结温度有关。具有介孔结构的H-HAMs具有许多潜在的应用，如作为药物缓释载体在硬组织系统的治疗中的应用。
Hollow hydroxyapatite microspheres (H-HAMs) with controlled characteristic mesoporous structure on the shell were successfully fabricated by using core template technology and sol-gel process. The fabrication of H-HAMs mainly included three distinct steps: the preparation of core template spheres of chitin by emulsifying chitin solution in oil, the formation of core-shell composite spheres of chitin-HA/chitin after a layer of chitin/HA solution coated on the surface of chitin core templates by means of a gelling process of chitin solution with the help of water in the cores, and the harvest of H-HAMs through a special sintering procedure to remove chitin. The size and shape of H-HAMs were chiefly determined by the size and morphology of core templates. The thickness of shells was easily controlled by altering water content of the starting template particles, and the characteristic mesoporous structure on the shell was related to the proportion of chitin in the chitin/HA composite solution and the sintering temperature. H-HAMs with characteristic mesoporous architecture on the shell have many potential applications such as used as a carrier for sustained release of drugs in the therapy of hard tissue system.