MULTIPLE-SCLEROSIS - HISTOPATHOLOGIC AND MR AND OR CT CORRELATION IN 37 CASES AT BIOPSY AND 3 CASES AT AUTOPSY
MULTIPLE-SCLEROSIS - HISTOPATHOLOGIC AND MR AND OR CT CORRELATION IN 37 CASES AT BIOPSY AND 3 CASES AT AUTOPSY
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DOI：
10.1148/radiology.180.2.2068314
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发表时间：
1991-08-01
期刊：
影响因子：
19.7
通讯作者：
RODRIGUEZ, M
中科院分区：
文献类型：
--
作者：
NESBIT, GM;FORBES, GS;RODRIGUEZ, M
作者回顾了40例经活检或尸检证实的炎性脱髓鞘与多发性硬化症(MS)一致的患者；每个患者都接受了磁共振(MR)和/或计算机断层扫描(CT)成像。在32例MR和30例CT检查中，有三种主要的X线表现：(A)相对较小的均匀病灶，无弥漫性强化或轻微弥漫性强化；(B)CT上的低密度病灶和短TRMR上的低信号病灶，有对比剂增强、等密度或等信号的环状；(C)更浸润性和边界不清的病变，密度和信号混杂，呈散在强化。一个共同的放射学特征是周围白质缺乏肿块效应或水肿，即使是大的病变。根据组织学和临床标准，除4例患者外，其余患者的皮损均为活动性病变。组织学上的活动性病变有不同的放射学表现；然而，在所有的增强研究中，它们都表现出某种形式的增强。非活动性病变在CT扫描上呈均匀低信号，在短TRMR图像上呈低信号，在平扫和长TRMR图像上呈高信号。
The authors retrospectively reviewed the cases of 40 patients with biopsy- or autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyperintense on unenhanced, long-TR MR images.