Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection
Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection
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DOI：
10.1016/j.joca.2008.03.022
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发表时间：
2008-11-01
影响因子：
7
通讯作者：
Pelletier, J. -P.
中科院分区：
文献类型：
--
作者：
d'Anjou, M. -A.;Troncy, E.;Pelletier, J. -P.
目的：利用三种不同的磁共振成像（MRI）序列评估犬膝骨关节炎（OA）模型骨髓病变（BMLs）的演变。设计：对5只前十字韧带横断后的犬，分别在基线和第4、8和26周进行3个MRI序列[冠状面、t1加权三维快速梯度回忆回波（T1-GRE）、矢状面脂肪抑制三维破坏梯度稳态回波（SPGR）和矢状面t2加权脂肪饱和快速旋转回波（T2-FS）]。同一位读者在盲法条件下，根据其在九个关节亚区的程度，在所有成像过程中，在三个MRI序列上独立地对软骨下BMLs进行了两次评分（0-3）。相关系数和Bland-Altman图评估阅读器内重复性。对阅读分数取平均值，对九个次区域进行求和，得出全球BML分数。结果：胫骨平台中部和内侧多见骨转移。每个序列的读卡器内重复性为良好至优异(r(s) = 0.87-0.97；P < 0.001)。在T2-FS上达到最大的读取器内变异性（24%），并与较高的评分相关（P < 0.05）。到第8周，三个序列的总体BML评分均有相似的升高（P < 0.05）。第26周时T2-FS评分降低，较T1-GRE、SPGR评分明显降低（P < 0.05）。在犬骨关节炎模型中，不同MRI序列的脑损伤程度随时间而变化。在这些病变的复杂性质得到完全解决之前，建议准确评估脑损伤的大小和程度，应使用不同序列的组合。(C) 2008国际骨关节炎研究学会。Elsevier Ltd.出版。版权所有。
Objective: To assess the evolution of bone marrow lesions (BMLs) in a canine model of knee osteoarthritis (OA) using three different magnetic resonance imaging (MRI) sequences.Design: Three MRI sequences [coronal, T1-weighted three-dimensional fast gradient recalled echo (T1-GRE), sagittal fat-suppressed 3D spoiled gradient echo at a steady state (SPGR), and sagittal T2-weighted fast spin echo with fat saturation (T2-FS)] were performed at baseline, and at week 4, 8 and 26 in five dogs following transection of the anterior cruciate ligament. The same reader scored (0-3) subchondral BMLs twice, in blinded conditions, according to their extent in nine joint subregions, for all imaging sessions, and independently on the three MRI sequences. Correlation coefficients and Bland-Altman plots evaluated intra-reader repeatability. Readings scores were averaged and the nine subregions were summed to generate global BML scores.Results: BMLs were most prevalent in the central and medial portions of the tibial plateau. Intra-reader repeatability was good to excellent for each sequence (r(s) = 0.87-0.97; P < 0.001). Maximal intra-reader variability (24%) was reached on T2-FS and was associated to higher scores (P < 0.05). Global BML scores increased similarly on all three sequences until week 8 (P < 0.05). At week 26, score on T2-FS was decreased, being lower when compared to T1-GRE and SPGR (P < 0.05).Conclusion. In this canine OA model, the extent of BMLs varies in time on different MRI sequences. Until the complex nature of these lesions is fully resolved, it is suggested that to accurately assess the size and extent of BMLs, a combination of different sequences should be used. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.