SINGLE SUBTHALAMIC NUCLEUS NEURONS PROJECT TO BOTH THE GLOBUS PALLIDUS AND SUBSTANTIA NIGRA IN RAT
SINGLE SUBTHALAMIC NUCLEUS NEURONS PROJECT TO BOTH THE GLOBUS PALLIDUS AND SUBSTANTIA NIGRA IN RAT
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DOI：
10.1002/cne.901920409
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
HATTORI, T
中科院分区：
文献类型：
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作者：
VANDERKOOY, D;HATTORI, T
采用荧光逆行双标记技术研究了大鼠丘脑底核（subthalamic nucleus，简称丘脑底核）主要传出神经的组织结构。将红色荧光新月形伊文思蓝注射到苍白球中，并将蓝色荧光DAPI-报春碱注射到黑质中。逆行轴突运输后，在整个脊髓中观察到许多双标记神经元。偶尔在外侧下丘脑中观察到双标记细胞，就在外侧下丘脑的内侧，以及从外侧下丘脑向外侧延伸的薄的外侧神经元带中。在苍白球和黑质通路中均发现了中外侧拓扑结构的证据，苍白球通路包含很少（如果有的话）局部中间神经元。细胞计数显示，至少有94%，可能是所有的，苍白球神经元发送轴突侧支到苍白球和黑质。
The organization of the major efferents of the rat subthalamic nucleus (STN) was investigated using a fluorescent retrograde double‐labeling technique. Red fluorcrescent Evans Blue was injected into the globus pallidus and blue fluorescent DAPI‐Primuline was injected into the substantia nigra. After retrograde axonal transport many double‐labeled neurons were seen throughout the STN. Occasional double‐labeled cells were seen in the lateral hypothalamus just medial to the STN and in a thin lateral strip of neurons extending laterally from the STN. Evidence for a mediolateral topography in both the STN‐pallidal and STN‐nigral pathways was obtained.The STN contains few, if any, local interneurons. Cell counts revealed that at least 94% of, and possibly all, STN neurons send axon collaterals to both the globus pallidus and substantia nigra.