Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia
Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia
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DOI：
10.1007/s00439-005-1320-1
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发表时间：
2005-08-01
期刊：
影响因子：
5.3
通讯作者：
Byerley, W
中科院分区：
文献类型：
--
作者：
Klei, L;Bacanu, SA;Byerley, W
我们报告的连锁分析，一个完全确定的人口来自海洋国家帕劳的家族性精神病。帕劳是南太平洋的一个群岛，目前人口约为23 000人。帕劳人民在人类历史上不久，大约2 000年前才在这些岛屿上定居。正如历史和遗传证据所表明的那样，该人群比大多数其他正在进行遗传研究的人群更加同质化，因此应该证明对于绘制对精神障碍易感性具有有意义影响的遗传变异非常有用。此外，在我们的研究中，基本上所有岛上的精神分裂症患者（150）和其他精神病患者（25）都参加了研究。通过对狭义（仅精神分裂症）和广义（所有精神病）诊断方案的分析，两点连锁分析表明，基因组的两个区域含有影响大多数家庭中责任的遗传变异，3q28（LOD=3.03）和17q32.2（LOD=2.80）。来自个体家系的结果也支持2q37.2、2p14和17p13可能含有重要的遗传变异。这些区域中的大多数都涉及到其他精神病的遗传研究，这些研究涉及的人群在身体上与这个大洋洲人群相距甚远，尽管有些（例如，3q28）似乎是精神分裂症连锁分析的新结果。
We report on linkage analysis of a completely ascertained population of familial psychosis derived from the oceanic nation of Palau. Palau, an archipelago of islands in the Southern Pacific, currently has a population of approximately 23,000 individuals. The peoples of Palau populated these islands recently in human history, approximately 2,000 years ago. As both historical and genetic evidence suggest, the population is far more homogeneous than most other populations undergoing genetic studies, and should therefore prove quite useful for mapping genetic variants having a meaningful impact on susceptibility to psychotic disorders. Moreover, for our study, essentially all on-island schizophrenics (150) and individuals with other psychotic disorders (25) participated. By analysis of narrow (only schizophrenia) and broad (all psychosis) diagnostic schemes, two-point linkage analyses suggest that two regions of the genome harbor genetic variants affecting liability in most families, 3q28 (LOD=3.03) and 17q32.2 (LOD=2.80). Results from individual pedigrees also support 2q37.2, 2p14, and 17p13 as potentially harboring important genetic variants. Most of these regions have been implicated in other genetic studies of psychosis in populations physically quite distant from this Oceanic population, although some (e.g., 3q28) appear to be novel results for schizophrenia linkage analyses.