Effects of pre-germinated brown rice on depression-like behavior in mice
Effects of pre-germinated brown rice on depression-like behavior in mice
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DOI：
10.1016/j.pbb.2006.12.008
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Noda, Yukihiro
中科院分区：
文献类型：
--
作者：
Mamiya, Takayoshi;Kise, Mitsuo;Noda, Yukihiro
在小鼠强迫游泳实验和习得性无助范式中，我们分别研究了预发芽糙米（PGBR）和精米（PR）颗粒与对照（AIN-93G）颗粒的抗抑郁样作用。各组小鼠分别饲喂微丸30 d。在强迫游泳试验第2天，PR或PGBR颗粒剂组小鼠的静止时间比对照组小鼠短。在习得性无助范式中，PGBR颗粒组小鼠的逃避失败次数明显少于对照组小鼠。与对照组相比，PGBR组前额皮质血清素（5-HT）水平升高，5-羟基吲哚乙酸（5-HIAA）水平未见升高，5-HIAA/5-HT比值降低。各组海马和纹状体5-HT和5-HIAA水平及比值无显著差异。在所有测试的大脑区域，去甲肾上腺素和3-甲氧基-4-羟基苯基乙二醇的水平都没有受到食物颗粒的影响。此外，我们未检测到三组大脑额叶皮层5-HT1A受体和5-HT转运体的表达差异。这些结果表明，小鼠额叶皮层中5-羟色胺水平的增加有助于PGBR颗粒的抗抑郁作用。(c) 2006爱思唯尔公司版权所有。
We investigated the antidepressant-like effects of pre-germinated brown rice (PGBR) and polished rice (PR) pellets, respectively, in comparison with control (AIN-93G) pellets in the forced swimming test and the learned helplessness paradigm in mice. Mice were fed respective pellets for 30 days. The immobility time on the 2nd day of the forced swimming test was shorter in mice fed with PR or PGBR pellets than in mice fed with control pellets. In the learned helplessness paradigm, the number of escape failures in mice fed with PGBR pellets was significantly smaller than that in mice fed with control pellets. Compared to the control group, an increase in serotonin (5-HT) levels, but not in 5-hydroxyindoleacetic acid (5-HIAA) levels, and a decrease in the 5-HIAA/5-HT ratio were observed in the frontal cortex of the PGBR group. There were no differences among the three groups in terms of 5-HT and 5-HIAA levels and their ratios in the hippocampus and striatum. The levels of noradrenaline and 3-methoxy-4-hydroxyphenylglycol were not affected by the food pellets in all the brain regions tested. Additionally, we could not detect any,differences in the expression of the 5-HT1A receptor and the 5-HT transporter in the frontal cortex of the three groups. These results suggest that the increase of 5-HT levels in the mouse frontal cortex contributes to the antidepressant-like effects of PGBR pellets. (c) 2006 Elsevier Inc. All rights reserved.