The interface between measurement and modeling of peripheral lung mechanics
The interface between measurement and modeling of peripheral lung mechanics
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DOI：
10.1016/j.resp.2005.04.021
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发表时间：
2005-08-25
影响因子：
2.3
通讯作者：
Lutchen, KR
中科院分区：
文献类型：
--
作者：
Bates, JHT;Lutchen, KR
肺周组织的力学特性对整个器官的整体功能至关重要，在许多肺部疾病的症状学中起着关键作用。我们首先回顾了用于研究周围肺力学的实验方法，包括逆行导管、肺泡囊、肺泡囊振荡器和强迫振荡技术。然后，我们讨论了这些技术提供的数据在肺的逆数学模型方面的解释，包括恒定相位模型。最后，我们描述了基于计算机断层扫描和磁共振成像等成像方式的数据构建解剖上准确的肺正向模型的努力。总之，这些不同的方法提供了大量信息，说明在肺部疾病动物模型和人类患者中，肺外周在机械功能方面的相对重要性。越来越多的证据表明，肺这一部分的收缩是哮喘严重程度的关键决定因素。(C)2005 Elsevier B.V.保留所有权利。
The mechanical properties of the lung periphery are vital to the overall function of the whole organ, and play a key role in the symptomatology of many lung diseases. We first review the experimental methodologies that have been used to investigate peripheral lung mechanics, including the retrograde catheter, the alveolar capsule, the alveolar capsule oscillator, and the forced oscillation technique. We then discuss the interpretation of the data provided by these techniques in terms of inverse mathematical models of the lung, including the constant-phase model. Finally, we describe efforts to construct anatomically accurate forward models of the lung based on data from imaging modalities such as computed tomography and magnetic resonance imaging. Together, these various approaches have provided a great deal of information about the relative importance of the lung periphery in mechanical function in animal models of lung disease and in human patients. An increasing body of evidence indicates that constriction in this part of the lung is a crucial determinant of the severity of asthma. (c) 2005 Elsevier B.V. All rights reserved.