Advances in mechanisms and signaling pathways of carbon nanotube toxicity.
Advances in mechanisms and signaling pathways of carbon nanotube toxicity.
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DOI：
10.3109/17435390.2015.1009187
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发表时间：
2015
期刊：
影响因子：
5
通讯作者：
Ma Q
中科院分区：
文献类型：
--
作者：
Dong J;Ma Q
碳纳米管（CNT）已发展成为具有多种工业和商业应用的新材料。相比之下，纳米级碳纳米管的物理化学性质使其具有产生毒性作用的能力。事实上，近年来，碳纳米管的潜在健康影响引起了广泛关注，因为它们已确定的毒理学和病理学后果，包括细胞毒性、炎症、纤维化、遗传毒性、肿瘤发生和免疫毒性。因此，迫切需要了解碳纳米管诱发毒性和病理的机制，以准确评估人类碳纳米管暴露的风险，并安全、负责任地开发和商业化纳米技术。在此，我们总结并讨论了该领域的最新进展，重点关注 CNT 与哺乳动物系统之间的分子相互作用，以及对 CNT 毒性发展重要的信号通路，如 NF-κB、NLRP3 炎症小体、TGF-β1、MAPK 和 p53 信号级联。根据本综述中总结的当前机制证据，我们期望在分子水平上为碳纳米管毒理学提供新的见解，并为预防碳纳米管暴露对健康造成的影响提供新的线索。此外，我们披露了纳米毒理学这一快速发展领域中仍然存在的问题，这将有助于确定未来的研究方向。
Carbon nanotubes (CNT) have been developed into new materials with a variety of industrial and commercial applications. In contrast, the physicochemical properties of CNT at the nanoscale render them the potency to generate toxic effects. Indeed, the potential health impacts of CNT have drawn a great deal of attention in recent years, owing to their identified toxicological and pathological consequences including cytotoxicity, inflammation, fibrosis, genotoxicity, tumorigenesis, and immunotoxicity. Understanding the mechanisms by which CNT induce toxicity and pathology is thus urgently needed for accurate risk assessment of CNT exposure in humans, and for safe and responsible development and commercialization of nanotechnology. Here, we summarize and discuss recent advances in this area with a focus on the molecular interactions between CNT and mammalian systems, and the signaling pathways important for the development of CNT toxicity such as the NF-κB, NLRP3 inflammasome, TGF-β1, MAPK, and p53 signaling cascades. With the current mechanistic evidence summarized in this review, we expect to provide new insights into CNT toxicology at the molecular level and offer new clues to the prevention of health effects resulting from CNT exposure. Moreover, we disclose questions and issues that remain in this rapidly advancing field of nanotoxicology, which would facilitate ascertaining future research directions.