A STUDY OF COXSACKIE-B VIRUS-INFECTIONS, 1972-1983
A STUDY OF COXSACKIE-B VIRUS-INFECTIONS, 1972-1983
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DOI：
10.1017/s0022172400064718
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
MCCARTNEY, RA
中科院分区：
文献类型：
--
作者：
BELL, EJ;MCCARTNEY, RA
报告了一项对多种急慢性疾病患者中柯萨奇病毒B （CBV）感染的为期12年的研究结果。仅从123例患者中分离出CBV，其中大多数是患有呼吸道疾病的儿童。成人的病毒诊断主要基于检测显著上升或静态高中和抗体滴度。在1972-1979年间，大多数调查集中在疑似病毒性心脏病的患者身上，其中12%的患者被发现具有诊断意义上的显著CBV滴度。在明确的心包炎患者的研究中，阳性人数增加到33%。1980年，临床兴趣转向CBV在肌痛性脑脊髓炎（ME）中的可能作用，这是一种多种症状的疾病。1983年对ME疑似病例的调查显示，在苏格兰西部，16%的人血清学呈阳性，而正常成年人的血清学阳性比例为4%[英国]。在有充分证据的ME患者中，这一数字上升到41%。临床医生对CBV中和抗体测试的需求在过去12年中有所增加，并且每年都在继续增加，特别是在慢性复发疾病患者中。
The results of a 12 yr study of coxsackievirus B (CBV) infections in patients with a variety of acute and chronic illnesses are reported. CBV were isolated from only 123 patients, most of whom were children with respiratory illness. Virus diagnosis in adults was based mainly on the detection of significant rising or static high neutralizing antibody titers. Between 1972-1979 most investigations centered on patients with suspected viral heart disease, 12% of whom were found to have diagnostically significant CBV titers. In studies on patients with definite myopericarditis, the number positive increased to 33%. In 1980 clinical interest switched to the possible role of CBV in myalgic encephalomyelitis (ME), an illness of diverse symptomatology. Investigation of suspected cases of ME in 1983 showed that 16% were serologically positive compared to 4% of normal adults in western Scotland, [UK]. In patients with well-documented ME this figure rose to 41%. The demand by clinicians for CBV neutralizing antibody tests has increased over the past 12 yr and continues to escalate annually, especially in patients with chronic relapsing illness.