Patterned sensory nerve stimulation enhances the reactivity of spinal Ia inhibitory interneurons
Patterned sensory nerve stimulation enhances the reactivity of spinal Ia inhibitory interneurons
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DOI：
10.1097/wnr.0000000000000335
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发表时间：
2015-03-25
期刊：
影响因子：
1.7
通讯作者：
Funase, Kozo
中科院分区：
文献类型：
--
作者：
Kubota, Shinji;Hirano, Masato;Funase, Kozo
模式感觉神经刺激已被证明在相互的Ia抑制回路中诱导可塑性变化。然而，这些变化背后的机制尚未被详细阐明。本研究的目的是确定模式感觉神经刺激是否能改变Ia抑制中间神经元的反应性。观察了10例健康人的Ia抑制程度、经颅磁刺激(TMS)对比目鱼肌(SOL)H反射的调节作用以及H反射最大波幅与M波最大波幅之比(H-max/M-max)。以胫前肌的运动阈值强度，每隔1 S(100 Hz~5列)对腓总神经进行图形电刺激，诱发Ia抑制环路活动的改变。记录刺激前、刺激后即刻和刺激后15min的Ia抑制、TMS条件性H反射幅度和H-max/M-max。在短潜伏期，图形电刺激显著增加了Ia的相互抑制程度，降低了TMS条件性H反射的幅度，这可能是由Ia抑制的中间神经元介导的。但对H-max/M-max无明显影响。我们的结果表明，图形感觉神经刺激可以调节Ia抑制中间神经元的活动，这种变化可能是由于Ia抑制中间神经元终末的突触修饰所致。这些结果可能有助于更清楚地理解重复感觉输入所产生的脊髓突触可塑性。版权所有(C)2015 Wolters Kluwer Health，Inc.保留所有权利。
Patterned sensory nerve stimulation has been shown to induce plastic changes in the reciprocal Ia inhibitory circuit. However, the mechanisms underlying these changes have not yet been elucidated in detail. The aim of the present study was to determine whether the reactivity of Ia inhibitory interneurons could be altered by patterned sensory nerve stimulation. The degree of reciprocal Ia inhibition, the conditioning effects of transcranial magnetic stimulation (TMS) on the soleus (SOL) muscle H-reflex, and the ratio of the maximum H-reflex amplitude versus maximum M-wave (H-max/M-max) were examined in 10 healthy individuals. Patterned electrical nerve stimulation was applied to the common peroneal nerve every 1 s (100 Hz-5 train) at the motor threshold intensity of tibialis anterior muscle to induce activity changes in the reciprocal Ia inhibitory circuit. Reciprocal Ia inhibition, the TMS-conditioned H-reflex amplitude, and H-max/M-max were recorded before, immediately after, and 15 min after the electrical stimulation. The patterned electrical nerve stimulation significantly increased the degree of reciprocal Ia inhibition and decreased the amplitude of the TMS-conditioned H-reflex in the short-latency inhibition phase, which was presumably mediated by Ia inhibitory interneurons. However, it had no effect on H-max/M-max. Our results indicated that patterned sensory nerve stimulation could modulate the activity of Ia inhibitory interneurons, and this change may have been caused by the synaptic modification of Ia inhibitory interneuron terminals. These results may lead to a clearer understanding of the spinal cord synaptic plasticity produced by repetitive sensory inputs. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.