Correlation between the aging males' symptoms scale and sex steroids, gonadotropins, dehydroepiandrosterone sulfate, and growth hormone levels in ambulatory men
Correlation between the aging males' symptoms scale and sex steroids, gonadotropins, dehydroepiandrosterone sulfate, and growth hormone levels in ambulatory men
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DOI：
10.1111/j.1743-6109.2006.00277.x
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发表时间：
2006-07-01
影响因子：
3.5
通讯作者：
Yokoyama, Osamu
中科院分区：
文献类型：
--
作者：
Miwa, Yoshiji;Kaneda, Taisei;Yokoyama, Osamu
导论.老年男性部分雄激素缺乏症（PADAM）是一种以血清雄激素水平缺乏为特征的与年龄增长相关的生化综合征。老年男性症状（AMS）量表用于评估PADAM相关症状，目前在全球范围内使用;然而，据报道，该量表评估的PADAM相关症状与血清睾酮水平无关。除了睾酮，其他激素的水平也随着年龄的增长而下降;因此，多激素的变化可能会影响PADAM相关的Aim。探讨男性PADAM相关症状与血清睾酮、雌二醇（E2）、促黄体生成素（LH）、促卵泡激素（FSH）、硫酸脱氢表雄酮（DHEA-S）和生长激素（GH）水平的关系。在排除患有内分泌和其他相关疾病的男性后，共招募了141名门诊男性。所有参与者完成AMS问卷和血清总睾酮和游离睾酮（TT和FT）、E2、LH、FSH、DHEA-S和GH水平分析。结果/年龄与血清FT、DHEA-S水平呈显著负相关，与LH、FSH水平呈正相关，与AMS评分无相关性。AMS三个领域量表评分和总分与血清TT、FT、E2、LH、FSH、DHEA-S或GH水平均无显著相关性。本研究的结果表明，AMS量表评估的PADAM相关症状与TT、FT、E2、LH、FSH、DHEA-S或GH的血清水平无显著相关性。由于许多与衰老相关的因素被认为有助于PADAM相关症状的发生，AMS量表可能无法预测血清激素水平。
Introduction. Partial androgen deficiency of the aging male (PADAM) is defined as a biochemical syndrome associated with advancing age that is characterized by a deficiency in serum androgen levels. The Aging Males' Symptoms (AMS) Scale was developed to evaluate PADAM-related symptoms and is currently used worldwide; however, it has been reported that PADAM-related symptoms evaluated by this scale are not related to serum testosterone levels. In addition to testosterone, the levels of other hormones also decrease with age; therefore, multihormone alterations may influence PADAM-related symptoms.Aim. To investigate the relationship between PADAM-related symptoms evaluated by the AMS Scale and serum levels of testosterone, estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEA-S), and growth hormone (GH) in men.Methods. A total of 141 ambulatory men were recruited after excluding men with endocrine and other related diseases. All participants completed the AMS questionnaire and an analysis of serum levels of total and free testosterone (TT and FT), E2, LH, FSH, DHEA-S, and GH.Main Outcome Measure. The relationship between AMS scores (total and subscores) and serum hormone levels was determined.Results/ There were significant negative correlations between age and serum FT and DHEA-S levels, as well as positive correlations between age and serum LH and FSH levels, but no correlation between age and AMS scores. None of the three AMS domain scale scores and total scores significantly correlated with serum levels of TT, FT, E2, LH, FSH, DHEA-S, or GH.Conclusions. The results of the present study suggest that PADAM-related symptoms as evaluated by the AMS Scale are not significantly related to serum levels of TT, FT, E2, LH, FSH, DHEA-S, or GH. Because many factors related to aging are thought to contribute to the occurrence of PADAM-related symptoms, the AMS Scale may not be able to predict serum hormone levels.