Alterations of the thrombin generation profile in rheumatoid arthritis
Alterations of the thrombin generation profile in rheumatoid arthritis
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DOI：
10.1007/s11239-015-1251-1
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发表时间：
2016-04-01
影响因子：
4
通讯作者：
Vasarhelyi, Barna
中科院分区：
文献类型：
--
作者：
Kern, Anita;Balog, Attila;Vasarhelyi, Barna
风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病，导致软骨和骨的侵蚀。全身受累，包括心血管系统，也可能发生动脉粥样硬化的风险。校准的自动血栓图（CAT）是一种市售的凝血酶生成试验，适用于凝血系统功能的一般评估。在这项研究中，我们在RA患者和未受影响的对照受试者（年龄，性别和合并症匹配）中进行了CAT测定。在CAT参数中，RA的速度指数增加（从60增加到83 nM/min），滞后时间和达峰时间减少（分别从3.47减少到2.83 min和从6.98减少到5.58 min）。另一方面，内源性凝血酶电位值降低（从1242至1108 nM min）。观察到的变化与应用的治疗无关。这些结果表明，凝血酶形成的速度增加，而凝血酶产生能力降低，在RA。
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder resulting in the erosion of the cartilage and bone. Systemic involvement including the cardiovascular system with the risk of atherosclerosis may also occur. Calibrated automated thrombogram (CAT), a commercially available thrombin generation assay is suitable for the general assessment of the functionality of coagulation system. In this study we performed CAT assay in RA patients and in non-affected control subjects (matched for age, sex and comorbidities). Among the CAT parameters Velocity Index increased (from 60 to 83 nM/min), Lag Time and Time to Peak decreased (from 3.47 to 2.83 min and from 6.98 to 5.58 min respectively) in RA. On the other hand, Endogenous Thrombin Potential values decreased (from 1242 to 1108 nM min). The observed alterations were not associated with the applied therapy. These results indicate that the velocity of thrombin formation is increased, while the thrombin generating capability is reduced in RA.