Imaging therapeutic response in human bone marrow using rapid whole-body MRI
Imaging therapeutic response in human bone marrow using rapid whole-body MRI
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DOI：
10.1002/mrm.20291
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发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Jakubowski, AA
中科院分区：
文献类型：
--
作者：
Ballon, D;Watts, R;Jakubowski, AA
使用生理水的扩散加权回波平面磁共振成像，在没有引入造影剂的情况下，实现了人体骨髓治疗反应的全身成像。通过选择性地激发水共振和产生依赖于不同核弛豫时间和自扩散系数的图像对比，相对于其他解剖学中来自水和脂肪的强烈覆盖信号，骨髓疾病被识别出来。生成三维显示以帮助图像解释。通过在全身多达12个解剖站采集多个轴位切片，使回波平面成像技术固有的几何失真最小化。所提供的例子包括在白血病和转移性前列腺癌的细胞毒治疗期间以及在干细胞采集之前的骨髓动员的细胞因子注射期间对骨髓治疗反应的评估。(C)2004年Wiley-Liss公司
Whole-body imaging of therapeutic response in human bone marrow was achieved without introduced contrast agents using diffusion-weighted echo-planar magnetic resonance imaging of physiologic water. Bone marrow disease was identified relative to the strong overlying signals from water and lipids in other anatomy through selective excitation of the water resonance and generation of image contrast that was dependent upon differential nuclear relaxation times and self-diffusion coefficients. Three-dimensional displays were generated to aid image interpretation. The geometric distortion inherent in echoplanar imaging techniques was minimized through the acquisition of multiple axial slices at up to 12 anatomic stations over the entire body. Examples presented include the evaluation of therapeutic response in bone marrow during cytotoxic therapy for leukemia and metastatic prostate cancer and during cytokine administration for marrow mobilization prior to stem cell harvest. (C) 2004 Wiley-Liss, Inc.