Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)
Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)
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DOI：
10.1007/978-3-319-58592-5_2
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Fukagawa, Tatsuo
中科院分区：
文献类型：
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作者：
Hara, Masatoshi;Fukagawa, Tatsuo
着丝点是一个大的蛋白质复合物，它组装在染色体的着丝粒上，以确保在m期染色体的忠实分离。在大多数真核生物中，着丝粒是由与DNA序列无关的机制在表观遗传上指定的。组成性着丝粒相关网络（CCAN）是着丝粒中的亚复合物，在整个细胞周期中定位于着丝粒。CCAN具有与着丝染色质和纺锤体微管结合复合物结合的界面；因此，它是着丝点形成的基础。在此，我们总结了近年来我们对CCAN的结构和组织的理解进展。我们还讨论了CCAN在维持着丝粒位置和CCAN动态重组中的额外作用。
The kinetochore is a large protein complex, which is assembled at the centromere of a chromosome to ensure faithful chromosome segregation during M-phase. The centromere in most eukaryotes is epigenetically specified by DNA sequence-independent mechanisms. The constitutive centromere-associated network (CCAN) is a subcomplex in the kinetochore that localizes to the centromere throughout the cell cycle. The CCAN has interfaces bound to the centromeric chromatin and the spindle microtubule-binding complex; therefore, it functions as a foundation of kinetochore formation. Here, we summarize recent progress in our understanding of the structure and organization of the CCAN. We also discuss an additional role of the CCAN in the maintenance of centromere position and dynamic reorganization of the CCAN.