Control of regulatory T cell development by the transcription factor Foxp3
Control of regulatory T cell development by the transcription factor Foxp3
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DOI：
10.1126/science.1079490
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发表时间：
2003-02-14
期刊：
影响因子：
56.9
通讯作者：
Sakaguchi, S
中科院分区：
文献类型：
--
作者：
Hori, S;Nomura, T;Sakaguchi, S
调节性T细胞通过主动抑制自身反应性淋巴细胞，参与免疫耐受的维持。然而，人们对它们发育的分子机制知之甚少。在这里，我们展示了Foxp3，它编码一种在人类和小鼠的自身免疫和炎症综合征中存在遗传缺陷的转录因子，在自然产生的CD4(+)调节T细胞中特异表达。此外，Foxp3逆转录病毒基因转移将初始T细胞转化为与自然产生的CD4(+)调节性T细胞相似的调节性T细胞表型。因此，Foxp3是调节性T细胞发育的关键调控基因。
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4(+) regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naive T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4(+) regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.