Parental history and the risk for childhood asthma - Does mother confer more risk than father?
Parental history and the risk for childhood asthma - Does mother confer more risk than father?
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DOI：
10.1164/ajrccm.158.1.9710014
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发表时间：
1998-07-01
影响因子：
24.7
通讯作者：
Gold, DR
中科院分区：
文献类型：
--
作者：
Litonjua, AA;Carey, VJ;Gold, DR
尽管遗传在哮喘和其他过敏性疾病中起着重要作用，但人们对这些疾病遗传的机制知之甚少，母亲和父亲的状况对疾病风险的相对影响也是如此。我们对 306 名中位年龄为 3.5 岁的儿童进行了调查，将医生诊断的母亲和父亲的哮喘、湿疹和花粉热作为儿童哮喘和过敏性疾病的横断面预测因子，这些儿童的家庭中至少有一位父母有哮喘或其他过敏性疾病史。对于儿童哮喘和湿疹，最强的父母预测因素是父母的情况相同。特别是对于哮喘，在单变量（OR = 3.2，95% CI = 1.5 至 6.7）和多变量（OR = 41，95% CI = 1.7 至 10.1）模型中，母亲哮喘与所有年龄段的儿童哮喘的相关性最强。在单变量模型中，父亲哮喘与儿童哮喘的相关性较弱（OR = 1.4，95% CI = 0.6 至 3.2），但在多变量模型中，这种相关性增强（OR = 2.7，95% CI = 1.0 至 7.2）。在<5岁的儿童中，与母亲哮喘相关的儿童哮喘风险（OR = 5.0，95% CI = 1.7至14.9）大于与父亲哮喘相关的风险（OR = 1.6，95% CI = 0.5至5.9），而在大于或等于5岁的儿童中，母亲哮喘和父亲哮喘与相似的风险相关（OR = 4.6， 95% CI = 1.1 至 19.0 和 OR = 4.1，95% CI = 1.0 至 16.0。与只有一位父母患有吸入性过敏但不患有哮喘的家庭相比，有一位父母患有哮喘的家庭中生出患有哮喘的孩子的几率高出三倍，而有两位父母患有哮喘的家庭则高出六倍；此外，父母一方的吸入性过敏也会在另一方父母患有哮喘的情况下带来额外的风险。需要进一步研究遗传因素以及子宫内和产后暴露的相对重要性，以确定母亲和父亲哮喘对儿童哮喘发展的不同影响。
Although heredity plays a major role in asthma and in other allergic diseases, mechanisms underlying the inheritance of these disorders are poorly understood, as is the relative contribution of maternal and paternal conditions to risk of disease. We investigated doctor-diagnosed maternal and paternal asthma, eczema, and hay fever as cross-sectional predictors of childhood asthma and allergic disease in 306 children with a median age of 3.5 yr from families in which at least one parent had a history of either asthma or other allergic conditions. For both childhood asthma and eczema, the strongest parental predictors were the same conditions in the parents. For asthma in particular, maternal asthma was most strongly associated with asthma in the child over all ages in both univariate (OR = 3.2, 95% CI = 1.5 to 6.7) and multivariable (OR = 41, 95% CI = 1.7 to 10.1) models. Paternal asthma was weakly associated with childhood asthma in the univariate model (OR = 1.4 95% CI = 0.6 to 3.2), but this association increased in magnitude in the multivariable model (OR = 2.7, 95% CI = 1.0 to 7.2). Among the children < 5 yr of age, the risk for childhood asthma associated with maternal asthma (OR = 5.0, 95% CI = 1.7 to 14.9) was greater than the risk associated with paternal asthma (OR = 1.6, 95% CI = 0.5 to 5.9), whereas both maternal asthma and paternal asthma were associated with similar risks among children greater than or equal to 5 yr of age (OR = 4.6, 95% CI = 1.1 to 19.0 and OR = 4.1, 95% CI = 1.0 to 16.0, respectively). The odds of having a child with asthma were three times greater in families with one asthmatic parent and six times greater in families with two asthmatic parents than in families where only one parent had inhalant allergy without asthma; furthermore, inhalant allergy in one parent also conferred additional risk in the presence of asthma in the other parent. Further investigation is needed into the relative importance of genetic factors and in utero and postnatal exposures in determining the differential effects of maternal and paternal asthma on the development of childhood asthma.