Throwing light on DARC
Throwing light on DARC
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DOI：
10.1042/bst0341005
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发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Rot, A.
中科院分区：
文献类型：
--
作者：
Pruenster, M.;Rot, A.
趋化因子在引导和驱动白细胞运输方面发挥着关键作用。趋化因子对白细胞募集的有效调节需要它们在功能显微解剖领域的适当定位，以及对它们在空间和时间上的影响设定限制。这两个过程都受到沉默的趋化因子受体(拦截器)的影响，包括DARC(趋化因子的Duffy抗原受体)。越来越多的实验证据表明，DARC参与了血管外趋化因子在血管内皮细胞的聚集，趋化因子的跨细胞转运和在其管腔表面的呈递，导致白细胞的黏附和迁移。此外，DARC在红细胞上表达，并可作为血液中趋化因子的汇集器。这限制了趋化因子通过血液传播到远处的器官和组织，并减少了它们对循环中的白细胞的影响。
Chemokines play a key role in directing and driving leucocyte trafficking. The efficient regulation of leucocyte recruitment by chemokines requires their appropriate localization in functional micro-anatomical domains, as well as setting limits to their effects in space and time. Both processes are influenced by silent chemokine receptors (interceptors), including DARC (Duffy antigen receptor for chemokines). increasing experimental evidence suggests that DARC is involved in accumulation of extravascular chemokines in endothelial cells, chemokine transcytosis and presentation on their luminal surface, leading to leucocyte adhesion and emigration. Additionally, DARC is expressed on erythrocytes and can act as a sink for chemokines in blood. This limits the dissemination of chemokines through blood into distant organs and tissues as well as reducing their effects on the circulating leucocytes.