Features of the metabolic syndrome and the risk of non-vertebral fractures: The Tromso study
Features of the metabolic syndrome and the risk of non-vertebral fractures: The Tromso study
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DOI：
10.1007/s00198-005-0003-z
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发表时间：
2006-03-01
影响因子：
4
通讯作者：
Joakimsen, RMJ
中科院分区：
文献类型：
--
作者：
Ahmed, LA;Schirmer, H;Joakimsen, RMJ
前言：我们想要检查代谢综合征的特征是否会增加非脊椎骨折的风险。方法：这是一项以人群为基础的为期6年的随访，从1994年到2001年对特罗姆索市的27,159名受试者进行了跟踪调查。年龄25~98岁。测定非空腹血清高密度脂蛋白(HDL)、甘油三酯、血糖、血压(BP)、体重和身高。所有非椎体骨折均通过计算机检索放射学档案进行登记。结果：共登记1,249例非椎体骨折。代谢综合征特征的增加与显著降低男性和女性的骨折风险相关，分别为p=0.004和p<；0.0001。在男性中，高血压对骨折有保护作用[相对风险(RR)0.89；95%可信区间(CI)0.8-0.99]，而增加体重指数(BMI)对女性有保护作用(RR为0.91；95%CI为0.84-0.98)。非空腹血清高密度脂蛋白水平升高会增加女性骨折风险(相对危险度1.12；95%可信区间1.05-1.21)。BMI改变了高密度脂蛋白对男性的影响。因此，高密度脂蛋白增加了高BMI男性的骨折风险(相对危险度1.51；95%可信区间1.2-1.9)。结论：增加代谢综合征的负担特征可以预防非脊椎骨折。非脊椎骨折风险的降低与男性的高血压和女性的体重增加有关。较低的非空腹血清高密度脂蛋白水平可预防女性和肥胖男性的骨折。
Introduction: We wanted to examine whether the features of the metabolic syndrome carried an increased risk of non-vertebral fracture. Methods: This is a population-based, 6-year follow-up of 27,159 subjects from the municipality of Tromso, followed from 1994 until 2001. Age range was 25-98 years. Non-fasting serum levels of high-density lipoprotein (HDL), triglycerides and glucose, blood pressure (BP), weight and height were measured at baseline. All non-vertebral fractures were registered by computerised search in radiographic archives. Results: A total of 1,249 non-vertebral fractures were registered. Increasing number of metabolic syndrome features was associated with significantly reduced fracture risk in both men and women, p= 0.004 and p < 0.0001, respectively. High BP was protective against fracture in men [relative risk (RR) 0.89; 95% confidence interval (CI) 0.8-0.99)] while increased body mass index (BMI) was protective in women (RR 0.91; 95% CI 0.84-0.98). Increasing non-fasting serum levels of HDL increased fracture risk in women (RR 1.12; 95% CI 1.05-1.21). BMI modified the effect of HDL in men. Accordingly, high HDL increased fracture risk in men with high BMI (RR 1.51; 95% CI 1.2-1.9). Conclusions: Increasing burden of metabolic syndrome features protects against non-vertebral fractures. Reduced non-vertebral fracture risk was associated with high BP in men and increased body mass in women. Lower non-fasting serum levels of HDL protect against fractures in women and obese men.