Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex
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DOI：
10.1126/science.1104882
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发表时间：
2005-03-18
期刊：
影响因子：
56.9
通讯作者：
Gietzen, DW
中科院分区：
文献类型：
--
作者：
Hao, SZ;Sharp, JW;Gietzen, DW
认识到蛋白质合成所必需的氨基酸（IAAs）的缺乏对于后生动物（包括人类）的饮食选择至关重要。大脑前梨状皮质（APC）中的细胞对IAA缺乏敏感，发出拒绝饮食和寻找补充IAA来源的信号，但其机制尚不清楚。在这里，我们报告的机制，用于识别IAA缺乏的食品如下保守的一般控制（GC）系统，其中不带电的转移RNA诱导磷酸化的真核起始因子2（eIF2）通过GC非去阻遏2（GCN 2）激酶。因此，哺乳动物大脑中营养应激管理的基本机制指导食物选择以维持生存。
Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Celts in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, Signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (elF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.