Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder
Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder
复制标题
重度抑郁症丘脑皮质网络内在功能连接异常
DOI：
10.1111/cns.12831
复制
发表时间：
2018-11-01
影响因子：
5.5
通讯作者：
Si, Tian-Mei
中科院分区：
文献类型：
--
作者：
Kong, Qing-Mei;Qiao, Hong;Si, Tian-Mei
目的：越来越多的证据表明抑郁症患者丘脑及其投射皮质靶点功能障碍。然而，由于丘脑的区域异质性和有限的检查方法，丘脑-皮质连接在严重抑郁障碍(MDD)中的解剖特异性仍不清楚。方法：收集70例MDD患者和70名健康对照的静息状态fMRI。丘脑根据与六个预定义的皮质感兴趣区(ROI)的连通性被分割。被分割的丘脑核团被用作种子，以绘制与整个大脑其余部分的连接。结果：大脑皮层感兴趣区与丘脑内不同区域呈正相关。我们发现MDD患者顶叶ROI到丘脑的连接性降低的趋势。重要的是，MDD患者表现出额叶前部和顶叶丘脑ROI与双侧额中回(MFG)和右侧后默认模式网络(DMN)之间的连接减少，以及额叶前部和运动丘脑ROI与外侧颞区之间的连接减少。相反，运动丘脑ROI与右侧MFG和右侧额叶内侧回/扣带前回之间、运动/体感丘脑ROI与右侧后DMN之间、额叶前部/体感丘脑ROI与小脑之间、顶叶丘脑ROI与左侧胰岛素之间的连接性增强。结论：本研究首次探讨了MDD丘脑-皮质连接性障碍的解剖学特征。MDD受试者表现出丘脑-皮质连接性改变，其特征是区域依赖性低或高连接性的复杂模式。因此，我们推测选择性地调节丘脑-皮质回路的连接可能是治疗MDD的一种潜在的新的治疗机制。
Objective: Growing evidence has implicated dysfunction of the thalamus and its projection cortical targets in depression. However, the anatomical specificity of thalamo-cortical connectivity in major depressive disorder (MDD) remains unknown due to the regional heterogeneity of the thalamus and limited methods to examine this.Methods: Resting-state fMRI was collected on 70 MDD patients and 70 healthy controls. The thalamus was parcellated based on connectivity with six predefined cortical regions of interest (ROIs). The segmented thalamic nuclei were used as seeds to map connectivity with the rest of the whole brain. The cortical-to-thalamus connectivity values and thalamus-based connectivity maps were compared between groups.Results: The cortical ROIs demonstrated correlations with spatially distinct zones within the thalamus. We found a trend toward reduced parietal ROI-to-thalamus connectivity in MDD. Importantly, MDD patients demonstrated reduced connectivity between prefrontal and parietal thalamus ROIs and bilateral middle frontal gyrus (MFG) and the right posterior default mode network (DMN) and between the prefrontal and motor thalamus ROIs and lateral temporal regions. Conversely, increased connectivity emerged between the motor thalamus ROI and right MFG and right medial frontal gyrus/anterior cingulate; between motor/somatosensory thalamus ROIs and right posterior DMN; between prefrontal/somatosensory thalamus ROIs and cerebellum; and between the parietal thalamus ROI and left insula.Conclusions: This study is the first to examine the anatomical specificity of thalamo-cortical connectivity disturbances in MDD. Subjects with MDD demonstrated altered thalamo-cortical connectivity characterized by a complex pattern of region-dependent hypo- or hyperconnectivity. We therefore speculate that selectively modulating the connectivity of thalamo-cortical circuitry may be a potential novel therapeutic mechanism for MDD.