Non-LDL dyslipidemia is prevalent in the young and determined by lifestyle factors and age: The LifeLines cohort
Non-LDL dyslipidemia is prevalent in the young and determined by lifestyle factors and age: The LifeLines cohort
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DOI：
10.1016/j.atherosclerosis.2018.05.016
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发表时间：
2018-07-01
期刊：
影响因子：
5.3
通讯作者：
Smit, Andries J.
中科院分区：
文献类型：
--
作者：
de Vries, Jeroen K.;Balder, Jan W.;Smit, Andries J.
背景和目的：非低密度脂蛋白血脂异常（NLD）具有心血管风险，在老年人群中患病率似乎很高。小型队列已经确定了几种与NLD相关的生活方式、人体测量学和医学因素。我们的目的是评估当代人群队列中NLD的性别和年龄特异性患病率（n = 167 729），并确定NLD的独立决定因素，重点是生活方式、人体测量学和医学因素。方法：对荷兰生命线队列中无心血管疾病且未使用脂质修饰药物的成人NLD的患病率进行每10年年龄间隔的评估。NLD被定义为低高密度脂蛋白胆固醇或高甘油三酯或高残余胆固醇，按照指导临界值。采用多变量回归确定与NLD独立相关的因素。决定因素包括年龄、吸烟、饮酒、体力活动、饮食、体重指数、糖尿病（DM）、慢性肾脏疾病，以及妇女的更年期状态和口服避孕药的使用。结果：在该队列中，NLD发生率为15-19%的女性和13-30%的男性，其中35-55岁男性的患病率最高，为30%。在大多数年龄组中，女性的患病率低于男性。肥胖（两性：优势比（OR） 5.3, 95%可信区间（95% CI） 5.0-5.7）、当前吸烟（男性：OR 1.8, 95% CI 1.7-1.9；女性：OR 2.2, 95% CI 2.1-2.3）和糖尿病（男性：OR 2.2, 95% CI 1.8-2.6；女性：OR 2.7, 95% CI 2.3-3.1）与NLD密切相关。结论：NLD已经在早期频繁发生。可改变的生活方式选择、肥胖和糖尿病是NLD的重要决定因素。公共卫生工作可大大有助于减少全国民盟。(C) 2018 Elsevier B.V.版权所有
Background and aims: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex-and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors.Methods: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort. NLD was defined as low HDL-cholesterol or high triglycerides or high remnant cholesterol as per guideline cut-off values. Multivariable regression was used to identify factors independently associated with NLD. Determinants included age, smoking, alcohol use, physical activity, diet, BMI, diabetes mellitus (DM), chronic kidney disease, and in women, menopausal state and oral contraceptive use.Results: NLD occurred in 15-19% of women and 13-30% of men in this cohort, with the highest prevalence of 30% in 35-55 year old men. In most age groups, the prevalence in women was lower than in men. Obesity (both sexes: Odds ratio (OR) 5.3, 95% confidence interval (95% CI) 5.0-5.7), current smoking (men: OR 1.8, 95% CI 1.7-1.9; women OR 2.2, 95% CI 2.1-2.3), and DM (men: OR 2.2, 95% CI 1.8-2.6; women: OR 2.7, 95% CI 2.3-3.1) were strongly associated with NLD.Conclusions: NLD already occurs frequently at an early age. Modifiable lifestyle choices, obesity, and DM were strong determinants of NLD. Public health efforts could substantially contribute to decrease NLD. (C) 2018 Elsevier B.V. All rights reserved.