Race and BMI modify associations of calcium and vitamin D intake with prostate cancer.
Race and BMI modify associations of calcium and vitamin D intake with prostate cancer.
复制标题
种族和BMI修改了钙和维生素D摄入量与前列腺癌的关联。
DOI：
10.1186/s12885-017-3060-8
复制
发表时间：
2017-01-19
期刊：
影响因子：
3.8
通讯作者：
Kittles RA
中科院分区：
文献类型：
--
作者：
Batai K;Murphy AB;Ruden M;Newsome J;Shah E;Dixon MA;Jacobs ET;Hollowell CM;Ahaghotu C;Kittles RA
非洲裔美国人的前列腺癌负担比欧洲裔美国人高得不成比例。然而，前列腺癌差异的原因仍不清楚。钙和维生素D在前列腺癌发生和发展中的作用已被提出，但流行病学研究主要是在欧洲血统人群中进行的。在这里，我们在多种族样本中调查了钙和维生素D摄入量与前列腺癌的关系。来自芝加哥、伊利诺伊州和华盛顿特区的1657名接受筛查和健康对照的前列腺癌患者(888名非洲裔美国人，620名欧洲裔美国人，111名西班牙裔美国人，以及38名其他人)被纳入这项研究。采用食物频率调查问卷评价钙和维生素D的摄入量。我们进行了调整相关变量的非条件Logistic回归分析。在汇集的数据集中，高钙摄入量与侵袭性前列腺癌的高风险显著相关(OR四分位1比四分位4 = 1.98，95%C.I.1.01-3.91)，而高维生素D摄入量与侵袭性前列腺癌的低风险相关(OR四分位1比四分位 = 0.38，95%C.I.：0.18-0.79)。在非裔美国人中，高钙摄入量与侵袭性前列腺癌之间的关联具有统计学意义(OR1分位数与4分位数 = 4.28，95%C.I.：1.7-10.80)。我们还观察到，在非裔美国人中，维生素D的总摄入量与前列腺癌之间存在强烈的负相关(OR1分位数与4分位数 = 分别为0.06和0.06，95%C.I.：0.02-0.54)。在欧洲美洲，我们没有观察到钙或维生素D摄入量与前列腺癌之间有任何显著的关联。在根据身体质量指数对参与者进行分层的分析中，我们观察到钙与侵袭性前列腺癌之间存在强烈的正相关关系，而维生素D摄入量与侵袭性前列腺癌之间存在强烈的负相关关系，在低体重指数(<；27.8亿公斤/平方米)的男性中，但在高体重指数男性(≥为27.8亿公斤/平方米)中则不然。种族和体重指数与维生素D摄入量的交互作用显著(P交互作用 <； 0.05)。钙摄入量与侵袭性前列腺癌呈正相关，而维生素D摄入量与侵袭性前列腺癌呈负相关。然而，这些关联因种族/民族和体重指数而异。这项研究的发现可能有助于开发更好的前列腺癌预防和管理策略。本文的在线版本(doi：10.1186/s12885-0173060-8)包含补充材料，授权用户可以使用。
African Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples. A total of 1,657 prostate cancer patients who underwent screening and healthy controls (888 African Americans, 620 European Americans, 111 Hispanic Americans, and 38 others) from Chicago, IL and Washington, D.C. were included in this study. Calcium and vitamin D intake were evaluated using food frequency questionnaire. We performed unconditional logistic regression analyses adjusting for relevant variables. In the pooled data set, high calcium intake was significantly associated with higher odds for aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 1.98, 95% C.I.: 1.01–3.91), while high vitamin D intake was associated with lower odds of aggressive prostate cancer (ORQuartile 1 vs. Quartile 4 = 0.38, 95% C.I.: 0.18–0.79). In African Americans, the association between high calcium intake and aggressive prostate cancer was statistically significant (ORQuartile 1 vs. Quartile 4 = 4.28, 95% C.I.: 1.70–10.80). We also observed a strong inverse association between total vitamin D intake and prostate cancer in African Americans (ORQuartile 1 vs. Quartile 4 = 0.06, 95% C.I.: 0.02–0.54). In European Americas, we did not observe any significant associations between either calcium or vitamin D intake and prostate cancer. In analyses stratifying participants based on Body Mass Index (BMI), we observed a strong positive association between calcium and aggressive prostate cancer and a strong inverse association between vitamin D intake and aggressive prostate cancer among men with low BMI (<27.8 kg/m2), but not among men with high BMI (≥27.8 kg/m2). Interactions of race and BMI with vitamin D intake were significant (P Interaction < 0.05). Calcium intake was positively associated with aggressive prostate cancer, while vitamin D intake exhibited an inverse relationship. However, these associations varied by race/ethnicity and BMI. The findings from this study may help develop better prostate cancer prevention and management strategies. The online version of this article (doi:10.1186/s12885-017-3060-8) contains supplementary material, which is available to authorized users.