Incidence of Alzheimer's disease in a rural community in India - The Indo-US Study
Incidence of Alzheimer's disease in a rural community in India - The Indo-US Study
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DOI：
10.1212/wnl.57.6.985
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发表时间：
2001-09-25
期刊：
影响因子：
9.9
通讯作者：
Ganguli, M
中科院分区：
文献类型：
--
作者：
Chandra, V;Pandav, R;Ganguli, M
目的：确定印度巴拉布加尔市农村人群中AD的总体发病率和年龄别发病率，并将其与宾夕法尼亚州莫农加赫拉山谷的美国参考人群的发病率进行比较。方法：对年龄大于或等于55岁的受试者进行为期两年的前瞻性流行病学研究，采用重复的认知和功能筛查，然后使用第4版《精神疾病诊断和统计手册》、美国国家神经与沟通障碍研究所和中风-阿尔茨海默病及相关疾病协会诊断标准和临床痴呆评定量表进行标准化临床评估。结果：65岁以上AD患者中CDR大于或等于0.5的AD发病率为3.24(95%CI：1.48~6.14)，大于或等于55岁的AD发病率为1.74(95%CI：0.84~3.20)。以1990年美国人口普查的年龄分布为标准，大于或等于65岁的人的总发病率为每1000人年4.7人，大大低于莫农加赫拉山谷每1000人年17.5人的相应比率。结论：这是印度次大陆首次报告的阿尔茨海默病发病率，而且似乎是有史以来报告的最低发病率之一。然而，随访持续时间相对较短，文化因素和其他潜在的混杂因素建议在解释这一发现时要谨慎。
Objective: To determine overall and age-specific incidence rates of AD in a rural, population-based cohort in Ballabgarh, India, and to compare them with those of a reference US population in the Monongahela Valley of Pennsylvania. Methods: A 2-year, prospective, epidemiologic study of subjects aged greater than or equal to 55 years utilizing repeated cognitive and functional ability screening, followed by standardized clinical evaluation using the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for the diagnosis, and the Clinical Dementia Rating scale for the staging, of dementia and AD. Results: Incidence rates per 1000 person-years for AD with CDR greater than or equal to0.5 were 3.24 (95% CI: 1.48-6.14) for those aged greater than or equal to 65 years and 1.74 (95% CI: 0.84-3.20) for those aged greater than or equal to 55 years. Standardized against the age distribution of the 1990 US Census, the overall incidence rate in those aged greater than or equal to 65 years was 4.7 per 1000 person-years, substantially lower than the corresponding rate of 17.5 per 1000 person-years in the Monongahela Valley. Conclusion: These are the first AD incidence rates to be reported from the Indian subcontinent, and they appear to be among the lowest ever reported. However, the relatively short duration of follow-up, cultural factors, and other potential confounders suggest caution in interpreting this finding.