AMYGDALOID CHANGES IN AGING AND DEMENTIA
AMYGDALOID CHANGES IN AGING AND DEMENTIA
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DOI：
10.1001/archneur.1980.00500590049006
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
KEMPER, TL
中科院分区：
文献类型：
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作者：
HERZOG, AG;KEMPER, TL
确定了老年晚期和老年性痴呆患者杏仁核体积和细胞堆积密度变化的分区分布。正常对照组显示出相对较少但仍显著的年龄相关变化。老年性痴呆患者的杏仁核发生非常明显的退变，这种退变优先影响形态学、发育学和连接上较古老的内侧核、内侧中央核和皮质核。这些发现增加了杏仁核参与老年性痴呆中发生的行为变化的可能性。
The divisional distribution of volumetric and cell-packing density changes in the amygdala in patients with advanced aging and senile dementia was determined. Normal controls show relatively little, but nevertheless significant, age-related change. The amygdala undergoes very marked degeneration in patients with senile dementia, which preferentially affects the morphologically, developmentally and connectionally older medial, medial central and cortical nuclei. These findings strengthen the possibility that the amygdala participates in the behavioral changes that occur in senile dementia.