SIGNIFICANCE OF BASAL INSULIN LEVELS IN EVALUATION OF INSULIN RESPONSE TO GLUCOSE IN DIABETIC AND NONDIABETIC SUBJECTS
SIGNIFICANCE OF BASAL INSULIN LEVELS IN EVALUATION OF INSULIN RESPONSE TO GLUCOSE IN DIABETIC AND NONDIABETIC SUBJECTS
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DOI：
10.1172/jci105646
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发表时间：
1967-01-01
影响因子：
15.9
通讯作者：
PORTE, D
中科院分区：
文献类型：
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作者：
BAGDADE, JD;BIERMAN, EL;PORTE, D
在37例碳水化合物耐量正常和异常的肥胖和非肥胖男性受试者中，空腹过夜（基础）后的胰岛素水平与3小时100 g口服葡萄糖耐量试验期间胰岛素浓度的增加直接相关。肥胖，而不是糖尿病，与基础胰岛素水平的升高有关。因此，肥胖预测与葡萄糖摄入的胰岛素反应的大小。当个体胰岛素值表示为相对于基础水平的百分比变化时，排除了肥胖的影响。所有糖耐量正常的受试者的胰岛素水平迅速上升5-7倍，并在口服葡萄糖后1小时达到峰值。相反，糖尿病反应在第1小时显著降低，在所有受试者中，胰岛素反应（通过计算胰岛素随时间变化的百分比曲线所限定的面积来定量）显示出与葡萄糖反应的显著负相关。因此，碳水化合物不耐受程度的增加与胰岛素反应的降低有关。胰岛素水平升高，无论是在基础状态还是对葡萄糖的反应，都与肥胖有关。
The levels of insulin after an overnight fast (basal) in 37 obese and nonobese male subjects with normal and abnormal carbohydrate tolerance was directly related to the increase in insulin concentration during a 3 hr. 100 g oral glucose tolerance test. Obesity, but not diabetes, was associated with an elevation of this basal insulin level. Thus obesity predicted with the magnitude of the insulin response to glucose ingestion. When the individual insulin values were expressed as percent change from the basal level, this effect of obesity was excluded. The insulin levels of all subjects with normal carbohydrate tolerance promptly rose 5-7, fold, and reached peak value 1 hr. after oral glucose. In contrast, the diabetic response was markedly reduced during the 1st hr., and maximal (but still subnormal) insulin levels were not attained until 2 hr. In all subjects the insulin response (quantitated by calculation of the area circumscribed by a plot of the per cent change in insulin with time) showed a significant inverse correlation with the glucose response. Thus increasing degrees of carbohydrate intolerance were associated with decreasing insulin responses. Elevated levels of insulin, in both the basal state and in response to glucose, were related to obesity.