Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka
Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka
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DOI：
10.1038/ki.2011.258
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发表时间：
2011-12-01
影响因子：
19.6
通讯作者：
Jones, Alison L.
中科院分区：
文献类型：
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作者：
Athuraliya, Nimmi T. C.;Abeysekera, Tilak D. J.;Jones, Alison L.
病因不明的慢性肾脏病（CKD）的全球患病率可能被低估。社区一级的流行病学研究很少，原因是缺乏国家登记册，而且对非传染性疾病的报告不够重视。在这里，我们描述了斯里兰卡中北部，中部和南部省份的三个农村人口的蛋白尿-CKD的患病率和疾病特征。采用随机整群抽样方法选择患者，对年龄大于19岁的患者进行持续性试纸蛋白尿筛查。Medawachchiya地区（中北部）的蛋白尿-CKD患病率为130/2600例患者，Yatinuwara地区（中部）为68/709例患者，Hambantota地区（南部）为66/2844例患者。这些CKD患者的平均年龄范围为44至52岁。糖尿病和长期高血压是Yatinuwara和Hambantota地区CKD的主要危险因素。在Medawachchiya地区，年龄超过60岁和农业与蛋白尿-CKD密切相关;然而，87%的患者的主要风险因素尚不确定。在这些患者中，26例进行了肾活检;组织学显示肾小管间质疾病。因此，病因不明的蛋白尿-CKD在斯里兰卡中北部省很普遍。相比之下，已知的危险因素与中部和南部省份的CKD相关。Kidney International（2011）80，1212-1221; doi：10.1038/ki.2011.258; 2011年8月10日在线发表
The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD and disease characteristics of three rural populations in the North Central, Central, and Southern Provinces of Sri Lanka. Patients were selected using the random cluster sampling method and those older than 19 years of age were screened for persistent dipstick proteinuria. The prevalence of proteinuric-CKD in the Medawachchiya region (North Central) was 130 of 2600 patients, 68 of 709 patients in the Yatinuwara region (Central), and 66 of 2844 patients in the Hambantota region (Southern). The mean ages of these patients with CKD ranged from 44 to 52 years. Diabetes and long-standing hypertension were the main risk factors of CKD in the Yatinuwara and Hambantota regions. Age, exceeding 60 years, and farming were strongly associated with proteinuric-CKD in the Medawachchiya region; however, major risk factors were uncertain in 87% of these patients. Of these patients, 26 underwent renal biopsy; histology indicated tubulointerstitial disease. Thus, proteinuric-CKD of uncertain etiology is prevalent in the North Central Province of Sri Lanka. In contrast, known risk factors were associated with CKD in the Central and Southern Provinces. Kidney International (2011) 80, 1212-1221; doi:10.1038/ki.2011.258; published online 10 August 2011