Dietary Antioxidant Insufficiency Is Associated With Increased Inflammatory Markers and Poorer Health-Related Quality of Life in Patients With Heart Failure.
Dietary Antioxidant Insufficiency Is Associated With Increased Inflammatory Markers and Poorer Health-Related Quality of Life in Patients With Heart Failure.
复制标题
膳食抗氧化剂不足与心力衰竭患者炎症标志物增加和健康相关生活质量较差有关。
DOI：
10.1097/jcn.0000000000000912
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lennie,TerryA
中科院分区：
文献类型：
--
作者：
Wu,Jia-Rong;Song,EunKyeung;Moser,DebraK;Lennie,TerryA
背景抗氧化剂不足、炎症标志物升高和健康相关生活质量（HRQOL）差在心力衰竭（HF）患者中普遍存在。目的本研究的目的是检查饮食抗氧化剂摄入量、炎症标志物和HF患者的HRQOL之间的关联。方法这是对265名完成4天食物日记的HF患者进行的二次分析。我们评估了10种抗氧化剂的摄入量：α-胡萝卜素、β-胡萝卜素、β-隐黄质、叶黄素、玉米黄质、番茄红素、维生素C和E、锌和硒。抗氧化剂不足反映为每种抗氧化剂的测量水平低于估计平均需求或低于抗氧化剂的中位数，而没有估计平均需求。炎症标志物包括血清C-反应蛋白、细胞因子（白细胞介素6和10）、肿瘤坏死因子-α和可溶性受体（sTNFR 1和sTNFR 2），采用酶免疫测定法进行评估。结果饮食抗氧化剂不足可预测C-反应蛋白（β= 0. 135，P=. 001）。032)和白细胞介素10（β=−. 155，P=. 027）。抗氧化剂不足程度较高的患者C反应蛋白水平较高，白细胞介素10水平较低。两组抗氧化剂不足（β= 0.13，P=. 049)C反应蛋白（β= 0.16，P=. 019)独立与较差的HRQOL，而调整协变量。ConclusionsDietary抗氧化剂不足与炎症和较差的HRQOL的标志物增加。改善HF患者的饮食质量可能是提高HRQOL的一个富有成效的研究领域。
BackgroundAntioxidant insufficiency, elevated inflammatory markers, and poor health-related quality of life (HRQOL) are prevalent in patients with heart failure (HF).ObjectiveThe objective of this study was to examine the associations among dietary antioxidant intake, inflammatory markers, and HRQOL in patients with HF.MethodsThis was a secondary analysis of 265 patients with HF who completed a 4-day food diary. We assessed intake of 10 antioxidants: alpha carotene, beta carotene, beta cryptoxanthin, lutein, zeaxanthin, lycopene, vitamins C and E, zinc, and selenium. Antioxidant insufficiency was reflected by a measured level for each antioxidant that was below the estimate average requirement or lower than median for antioxidants without an estimate average requirement. Inflammatory markers including serum C-reactive protein, cytokines (interleukins 6 and 10), tumor necrosis factor-alpha, and soluble receptors (sTNFR1 and sTNFR2) were assessed with enzyme immunoassay. Health-related quality of life was measured using the Minnesota Living with Heart Failure at 12 months.ResultsDietary antioxidant insufficiency predicted C-reactive protein (β= 0.135, P=. 032) and interleukin 10 (β=−. 155, P=. 027). Patients with higher antioxidant insufficiency had higher C-reactive protein and lower interleukin 10. Both antioxidant insufficiency (β= 0.13, P=. 049) and higher C-reactive protein (β= 0.16, P=. 019) were independently associated with poorer HRQOL while adjusting for covariates.ConclusionsDietary antioxidant insufficiency was associated with increased markers of inflammation and poorer HRQOL. Improvement of diet quality among patients with HF may be a fruitful area of research for enhancing HRQOL.