Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
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DOI：
10.1038/ncomms8208
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发表时间：
2015-06-01
影响因子：
16.6
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
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作者：
Draisma, Harmen H. M.;Pool, Rene;Boomsma, Dorret I.
代谢物是参与细胞代谢的小分子，其可以使用代谢组学技术在生物样品中检测。在这里，我们提出了全基因组关联和荟萃分析的结果，如Biocrates代谢组学平台测量的129种代谢物的血清水平的变化。在7,478个欧洲血统个体的发现样本中，我们发现4,068个基因组和代谢组显著（Z检验，P
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome-and metabolome-wide significant (Z-test, P