Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane
Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane
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DOI：
10.1101/2023.03.31.534658
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发表时间：
2023-04
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通讯作者：
Takeshi Nishimura;S. Mori;Hiromasa Shikata;Moritaka Nakamura;Yasuko Hashiguchi;Yoshinori Abe;Takuma Hagihara;Hiroshi Y. Yoshikawa;M. Toyota;T. Higaki;M. Morita
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作者：
Takeshi Nishimura;S. Mori;Hiromasa Shikata;Moritaka Nakamura;Yasuko Hashiguchi;Yoshinori Abe;Takuma Hagihara;Hiroshi Y. Yoshikawa;M. Toyota;T. Higaki;M. Morita
生物体在重力作用下进化，并通过特殊细胞中的平衡石感知重力的方向。在有花植物的向重力性中，重力感应细胞中积累淀粉的质体（造粉体）起平衡石的作用。重力感应机制一直被认为是淀粉体向细胞内结构传递力的机械感应过程，但其分子支撑作用尚未见报道。这项研究表明，LAZY 1-LIKE家族蛋白参与的重力信号在平衡细胞定位到造淀粉体外周和其近端质膜，导致极性定位根据重力的方向。我们提出了一种重力传感机制，LZY通过该机制传递淀粉体的位置信息，即，通过转移到质膜上来改变重力的方向。
Organisms have evolved under the gravitational force and sense the direction of gravity via statoliths in specialized cells. In the gravitropism of flowering plants, the starch-accumulating plastids, amyloplasts, in gravity sensing cells act as statoliths. The gravity sensing mechanism has long been considered a mechanosensing process by which amyloplasts transmit forces to intracellular structures, but the molecular support has not been reported. This study revealed that LAZY1-LIKE family proteins involved in gravity signaling in statocytes are localized to the amyloplast periphery and its proximal plasma membrane, resulting in polar localization according to the direction of gravity. We propose a gravity sensing mechanism by which LZY transmits the positional information of amyloplasts, i.e., the direction of gravity, by translocating to the plasma membrane.