Pathological changes of the three clinical types of laryngeal burns based on a canine model
Pathological changes of the three clinical types of laryngeal burns based on a canine model
复制标题
基于犬模型的喉部烧伤三种临床类型的病理变化
DOI：
10.1016/j.burns.2013.06.010
复制
发表时间：
2014-03-01
期刊：
影响因子：
2.7
通讯作者：
Zhang Guo-An
中科院分区：
文献类型：
--
作者：
Wang Cheng;Zhao Ran;Zhang Guo-An
目的：本研究旨在研究吸入性喉烧伤三种临床类型（充血型、水肿型和阻塞型）的病理变化。将18只健康雄性成年Beagle犬随机分为两组，分别吸入室温（C组）、80 ℃（1组）160 ℃（组2）或320 ℃（组3）20 min诱导吸入性损伤。根据“喉烧伤早期临床评分和分型系统”对每个喉进行评估和评分。组织样本的会厌，喉前庭，声带和声门下腔的喉进行了显微镜下观察和评估的基础上`病理评分system.Results：病理变化的喉组1和2的主要特点是轻微的粘膜萎缩和轻度水肿的粘膜下组织。第3组喉呈水肿型和萎缩型两种不同的病理改变。萎缩型喉的临床评分（29.5 ± 0.7）低于水肿型喉（44.3 ± 2.1），病理评分（18.6 ± 3.2）高于水肿型喉（13.7 ± 1.8）。萎缩型喉烧伤早期发生喉梗阻的危险性较小，但预后不佳。(C)2013 Elsevier Ltd和ISBI。All rights reserved.
Objective: The study was designed to examine pathological changes of inhalational laryngeal burns of three clinical types: congestive, oedematous and obstructive.Methods: A total of 18 healthy, male, adult Beagle dogs were randomly assigned to inhale hot dry air at room temperature (group C), 80 degrees C (Group 1), 160 degrees C (Group 2) or 320 degrees C (Group 3) for 20 min to induce inhalation injury. Each larynx was evaluated and scored based on the 'clinical scoring and typing system of laryngeal burns at early stage'. Tissue samples of the epiglottis, laryngeal vestibule, vocal folds and infraglottic cavity of the larynx were observed microscopically and evaluated based on a `pathological scoring system.Results: Pathological changes of the larynxes of groups 1 and 2 were primarily characterised by slight atrophy of the mucosa and mild oedema of the submucosal tissues. Group 3 larynxes showed two distinct pathological changes: oedematous and atrophic types. The larynxes of the atrophic type showed lower clinical scores (29.5 +/- 0.7 vs. 44.3 +/- 2.1) but higher pathological scores (18.6 +/- 3.2 vs. 13.7 +/- 1.8) than the larynxes of the oedematous type.Conclusion: Severe laryngeal burns could manifest as severe laryngeal oedema or atrophic change. The laryngeal burns of the atrophic type might suggest an unsatisfactory prognosis, although it had less risk of laryngeal obstruction at an early stage. (C) 2013 Elsevier Ltd and ISBI. All rights reserved.