Teaching Tip: Implementing Scrum Wholesale in the Classroom
Teaching Tip: Implementing Scrum Wholesale in the Classroom
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教学技巧：在课堂上实施 Scrum Wholesale
DOI：
10.1002/1097-4695(20001105)45:2
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Corey Baham
中科院分区：
文献类型：
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作者：
Corey Baham
体外培养揭示了大量关于生长锥行为的信息，特别是对导向分子的反应，无论是积极的还是消极的，以及介导这些反应的信号系统。然而，很少有人知道这些事件，因为它们发生在体内。通过新的成像方法，可以在完整或半完整系统的复杂环境中记录生长锥行为。以通过视交叉的视网膜投射为模型，我们检验了先前从静态材料中得出的假设，即生长锥形式是位置特异性的：生长锥形式实际上反映了特定的行为，包括延伸的速率和克里思，这些行为在生长锥所在的不同位置或多或少地突出。其他研究表明，生长锥与沿着这条通路的细胞相互作用，既有专门的非神经元细胞，也有其他神经元，其中一些表达已知的导向分子。目前的挑战是桥梁动态成像与电子显微镜和分子定位，以连接生长锥的行为与细胞和分子的相互作用，在自然环境中，生长锥延伸。© 2000 John Wiley & Sons，Inc. J Neurobiol 44：260-270，2000
Studiesin vitrohave revealed a great deal about growth cone behaviors, especially responses to guidance molecules, both positive and negative, and the signaling systems mediating these responses. Little, however, is known about these events as they take placein vivo. With new imaging methods, growth cone behaviors can be chronicled in the complex settings of intact or semi‐intact systems. With the retinal projection through the optic chiasm as a model, we examined the hypothesis previously drawn from static material that growth cone form is position‐specific: growth cone form in fact reflects specific behaviors, including rate and tempo of extension, that are more or less prominent in different locales in which growth cones are situated. Other studies show that growth cones interact with cells along the pathway, both specialized nonneuronal cells and other neurons, some expressing known guidance molecules. The present challenge is to bridge dynamic imaging with electron microscopy and molecular localization, in order to link growth cone behaviors with cell and molecular interactions in the natural setting in which growth cones extend. © 2000 John Wiley & Sons, Inc. J Neurobiol 44: 260–270, 2000