Relaxation and immunity enhancement effects of γ-Aminobutyric acid (GABA) administration in humans
Relaxation and immunity enhancement effects of γ-Aminobutyric acid (GABA) administration in humans
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DOI：
10.1002/biof.5520260305
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发表时间：
2006-01-01
期刊：
影响因子：
6
通讯作者：
Yokogoshi, H.
中科院分区：
文献类型：
--
作者：
Abdou, Adham M.;Higashiguchi, S.;Yokogoshi, H.
口服γ -氨基丁酸（GABA）对人体应激状态下放松和免疫的影响已被研究。进行了两项研究。第一项研究评估了13名受试者摄入GABA对脑电波的影响。每名志愿者在只摄入水、GABA和l -茶氨酸3种测试后获得脑电图（EEG）。在给药60分钟后，与水或l -茶氨酸相比，GABA显著增加了α波，减少了β波。这些发现表明，GABA不仅能诱导放松，还能减少焦虑。第二项研究是为了观察GABA摄入对应激志愿者免疫的松弛和抗焦虑作用。8名恐高受试者分为安慰剂组和GABA组。作为压力刺激，所有受试者都要通过一座悬索桥。在过桥过程中监测唾液中的免疫球蛋白A （IgA）水平。安慰剂组IgA水平明显降低，而GABA组IgA水平明显升高。综上所述，GABA是一种有效的天然松弛剂，在给药1小时内就能看到其诱导放松和减轻焦虑的效果。此外，GABA可以增强应激条件下的免疫功能。
The effect of orally administrated gamma-Aminobutyric acid (GABA) on relaxation and immunity during stress has been investigated in humans. Two studies were conducted. The first evaluated the effect of GABA intake by 13 subjects on their brain waves. Electroencephalograms (EEG) were obtained after 3 tests on each volunteer as follows: intake only water, GABA, or L-theanine. After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to see the role of relaxant and anxiolytic effects of GABA intake on immunity in stressed volunteers. Eight acrophobic subjects were divided into 2 groups (placebo and GABA). All subjects were crossing a suspended bridge as a stressful stimulus. Immunoglobulin A (IgA) levels in their saliva were monitored during bridge crossing. Placebo group showed marked decrease of their IgA levels, while GABA group showed significantly higher levels. In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.