Increased visual cortical excitability in ecstasy users: a transcranial magnetic stimulation study
Increased visual cortical excitability in ecstasy users: a transcranial magnetic stimulation study
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DOI：
10.1136/jnnp.74.8.1136
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发表时间：
2003-08-01
影响因子：
11
通讯作者：
Calvo, G
中科院分区：
文献类型：
--
作者：
Oliveri, M;Calvo, G
目的：要测试的存在异常的视觉皮层兴奋性的人使用摇头丸作为一种娱乐性drug.Methods：摇头丸用户和对照组进行了单脉冲经颅磁刺激（TMS）的枕叶皮层。结果：摇头丸使用者的光幻视阈值明显低于对照组，且与摇头丸使用频率呈负相关。使用频率与幻视的存在呈正相关。有幻觉的受试者的光幻视阈值显着低于没有hallucinations.Conclusions的受试者：使用摇头丸作为一种娱乐性药物与视觉皮层的兴奋性增加，可能与大量的5-羟色胺释放，其次是5-羟色胺耗尽，在这个皮层区域。
Objectives: To test the presence of abnormalities of visual cortical excitability in people using ecstasy as a recreational drug.Methods: Ecstasy users and control subjects underwent single pulse transcranial magnetic stimulation (TMS) of the occipital cortex. The phosphene threshold was analysed and compared in the two groups.Results: Phosphene thresholds were significantly lower in ecstasy users compared with control subjects, and were correlated negatively with frequency of ecstasy use. Frequency of use was positively correlated with the presence of visual hallucinations. The phosphene threshold of subjects with hallucinations was significantly lower than that of subjects without hallucinations.Conclusions: The use of ecstasy as a recreational drug is associated with an increased excitability of the visual cortex, possibly linked with massive serotonin release, followed by serotonin depletion, in this cortical area.