Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae
Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae
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DOI：
10.1007/s12272-012-1006-x
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
El-Halawany, Ali M.
中科院分区：
文献类型：
--
作者：
Hawas, Usama W.;El-Beih, Ahmed Atef;El-Halawany, Ali M.
从红海绿色仙人掌（Halimeda opuntia）的内部组织中分离到一株海洋真菌--杂色曲霉（Aspergillus versicolor）。通过形态学观察和18 S rDNA鉴定该菌。该真菌菌株的培养产生了一种新的代谢产物，命名为异紫丁香苷-1-甲基醚（1）沿着产生的还有已知化合物大黄素（2）、1-甲基大黄素（3）、依伐醌（4）、7-羟基大黄素6，8-甲基醚（5）、铁黄素（6）、arugosin C（7）和variculanol（8）。根据核磁共振波谱分析和质谱分析鉴定了结构。对乙酸乙酯提取物和化合物1-3、6-8的抑菌活性、抗癌活性和对丙型肝炎病毒（HCV）蛋白酶的抑制作用进行了研究。
The marine fungus Aspergillus versicolor was isolated from the inner tissue of the Red Sea green alga Halimeda opuntia. The fungus was identified by its morphology and 18s rDNA. Cultivation of this fungal strain led to a new metabolite named isorhodoptilometrin-1-methyl ether (1) along with the known compounds emodin (2), 1-methyl emodin (3), evariquinone (4), 7-hydroxyemodin 6,8-methyl ether (5), siderin (6), arugosin C (7), and variculanol (8). The structures were elucidated on the basis of NMR spectroscopic analysis and mass spectrometry. The biological properties of ethyl acetate extract and compounds 1-3 and 6-8 were explored for antimicrobial activity, anti-cancer activity and inhibition of Hepatitis C virus (HCV) protease.