Design and testing of paramagnetic liposome-based CEST agents for MRI visualization of payload release on pH-induced and ultrasound stimulation
Design and testing of paramagnetic liposome-based CEST agents for MRI visualization of payload release on pH-induced and ultrasound stimulation
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DOI：
10.1007/s00775-013-1042-0
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发表时间：
2014-02-01
影响因子：
3
通讯作者：
Aime, Silvio
中科院分区：
文献类型：
--
作者：
Castelli, Daniela Delli;Boffa, Cinzia;Aime, Silvio
纳米药物在癌症治疗中的发展不断增长，因为与使用纳米药物递送系统相关的优势。其中，精确时空控制化疗剂从载体释放的可能性是最令人感兴趣和临床相关的。为了进一步改善治疗结果，用于释放步骤的体内可视化的成像方案的临床翻译是至关重要的。在这项工作中，脂质体的巨大的化学多功能性和MRI化学交换饱和转移剂的突出潜力的组合已成功地利用图像的内源性（pH值的变化）和外部施加（非聚焦超声）刺激刺激的脂质体内容物的选择性释放。使用临床安全的成分（脂质体和MRI试剂）和在体外获得的良好结果为未来成功的体内翻译提供了希望。
The development of nanomedicines in cancer therapy is constantly growing because of the advantages associated with the use of nanosized drug delivery systems. Among them, the possibility of accurate spatiotemporal control of the release of the chemotherapeutic from the carrier is one of the most interesting and clinically relevant. To further improve the therapy outcome, the clinical translation of imaging protocols for the in vivo visualization of the release step is of paramount importance. In this work, the combination of the great chemical versatility of liposomes and the outstanding potential of MRI chemical exchange saturation transfer agents has been successfully harnessed to image the selective release of the liposomal content stimulated by endogenous (variation of pH) and externally applied (nonfocused ultrasound) stimuli. The use of clinically safe components (both liposomes and MRI agents) and the good results obtained in vitro hold promise for a successful future in vivo translation.