Insulin-like growth factor-I axis as a pathway for cancer chemoprevention
Insulin-like growth factor-I axis as a pathway for cancer chemoprevention
复制标题
DOI：
10.1158/1078-0432.ccr-06-1564
复制
发表时间：
2006-10-01
影响因子：
11.5
通讯作者：
Mukhtar, Hasan
中科院分区：
文献类型：
--
作者：
Adhami, Vaqar Mustafa;Afaq, Farrukh;Mukhtar, Hasan
尽管化学预防正在成为癌症控制的一种现实和明智的方式，但对致癌过程中涉及的分子生物标记物和遗传特征的了解将进一步使个性化的化学预防方案能够有针对性地开发。胰岛素样生长因子(IGF)-I对正常生长是必不可少的；然而，研究表明，循环中IGF-I水平较高的人患常见癌症的风险会增加，如结肠癌(1)、乳腺癌(2)和前列腺癌(3)。增加的IGF-I信号刺激癌细胞的增殖和促进转移，因此是治疗和预防癌症的一个有希望的靶点(4-8)。
Even as chemoprevention is emerging as a realistic and a sensible modality for cancer control, knowledge on the molecular biomarkers and genetic signatures involved in the process of carcinogenesis will further allow customized targeted development of chemopreventive regimens for individualized needs. Insulin-like growth factor (IGF)-I is essential for normal growth; however, studies indicate that the risk of common cancers, such as colon (1), breast (2), and prostate (3), is increased in individuals who have higher circulating levels of IGF-I. Increased IGF-I signaling stimulates proliferation and promotes metastasis of cancer cells and therefore represents a promising target for treatment as well as prevention of cancer (4–8).