Histamine catabolism in male and female mice, guinea-pigs and rabbits.
Histamine catabolism in male and female mice, guinea-pigs and rabbits.
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雄性和雌性小鼠、豚鼠和兔子的组胺分解代谢。
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
H. Wetterqvist
中科院分区：
文献类型：
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作者：
H. Wetterqvist
本文研究了雄性和雌性小鼠、豚鼠和家兔的尿中组胺排泄、皮下注射放射性组胺后尿中放射性组胺的排泄以及放射性组胺在离体肾组织中的灭活作用。在雄性和雌性小鼠皮下注射放射性组氨酸后，尿中放射性组胺的排泄量也作了研究，豚鼠和家兔尿中组胺的排泄量无明显性别差异。在小鼠中，雌性小鼠的组胺尿排泄量显著大于雄性小鼠。该差异取决于皮下注射放射性组氨酸后放射性组胺尿排泄的测量结果显示，雌性动物中组胺形成率较高。小鼠、豚鼠和家兔皮下注射放射性组织胺后，尿中放射性组织胺的排泄率在两性之间基本相同，但在两性之间有差异。
Male and female mice, guinea-pigs and rabbits were studied concerning urinary excretion of histamine, urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histamine and inactivation of radioactive histamine in kidney tissue in vitro. In male and female mice the urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histidine was also investigated.There was no obvious sex difference in the urinary excretion of histamine in guinea-pigs and in rabbits. In mice the urinary excretion of histamine was significantly larger in females than in males. The difference depended on a higher rate of histamine formation in females as shown by measurements of the urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histidine. The percentage urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histamine was about the same in both sexes in mice, guinea-pigs and rabbits, but varied bet...