Psychotropic medication withdrawal and a home-based exercise program to prevent falls: A randomized, controlled trial
Psychotropic medication withdrawal and a home-based exercise program to prevent falls: A randomized, controlled trial
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DOI：
10.1111/j.1532-5415.1999.tb03843.x
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发表时间：
1999-07-01
影响因子：
6.3
通讯作者：
Buchner, DM
中科院分区：
文献类型：
--
作者：
Campbell, AJ;Robertson, MC;Buchner, DM
目的：评估精神药物停药和家庭锻炼计划在减少老年人福尔斯方面的有效性。设计：一项2 × 2析因设计的随机对照试验。设置：新西兰达尼丁的17个全科诊所。参与者：65岁的女性和男性在全科医生处注册，目前正在服用精神药物（n = 93）。干预：两种干预：（1）逐渐停用精神药物与继续服用精神药物（双盲）和（2）以家庭为基础的锻炼计划与没有锻炼计划（单盲）。结果：44周后，停药组与服用原始药物组相比，福尔斯跌倒的相对危险度为0.34（95%CI，0.16 - 0.74）。与那些没有收到的运动program.Conclusions：撤回精神药物治疗显着降低跌倒的风险，但永久退出是很难实现的运动计划组相比，下降的风险没有显着降低。
OBJECTIVE: To assess the effectiveness of psychotropic medication withdrawal and a home-based exercise program in reducing falls in older people.DESIGN: A randomized controlled trial with a two by two factorial design.SETTING: Seventeen general practices in Dunedin, New Zealand.PARTICIPANTS: Women and men aged 65 years registered with a general practitioner and currently taking psychotropic medication (n = 93).INTERVENTIONS: Two interventions: (1) gradual withdrawal of psychotropic medication versus continuing to take psychotropic medication (double blind) and (2) a home-based exercise program versus no exercise program (single blind).MEASUREMENTS: Number of falls and falls risk during 44 weeks of follow-up. Analysis was on an intent to treat basis.RESULTS: After 44 weeks, the relative hazard for falls in the medication withdrawal group compared with the group taking their original medication was .34 (95% CI, .16-.74). The risk of falling for the exercise program group compared with those not receiving the exercise program was not significantly reduced.CONCLUSIONS: Withdrawal of psychotropic medication significantly reduced the risk of falling, but permanent withdrawal is very difficult to achieve.