Cotinine as a marker for risk prediction in the Ludwigshafen Risk and Cardiovascular Health Study
Cotinine as a marker for risk prediction in the Ludwigshafen Risk and Cardiovascular Health Study
复制标题
DOI：
10.1016/j.resp.2014.10.008
复制
发表时间：
2015-04-01
影响因子：
2.3
通讯作者：
Kleber, Marcus E.
中科院分区：
文献类型：
--
作者：
Delgado, Graciela;Siekmeier, Ruediger;Kleber, Marcus E.
背景：可替宁是尼古丁的主要代谢产物之一。我们的研究的目的是探讨可替宁作为个体风险预测在路德维希港风险和心血管healthstudy.Methods的标志物：840个样本有可替宁检测使用放射免疫测定（RIA尼古丁代谢物，DPC Biermann GmbH）。通过ANOVA分析可替宁或包-年的四分位数的风险因素分布，并通过考克斯回归分析可替宁和包-年与死亡率的关联。在校正模型中，可替宁和包年均显示与死亡率显著相关，HR（95%CI）为1.30（1.17-1.44）和1.26（1.13-1.42），分别比较了可替宁和包年的第三个三分位数和第一个三分位数。无论是可替宁或包年或自我报告的吸烟增加曲线下面积显着相比，一个基本的模型，包括其他risk factors.Discussion：可替宁是一个强有力的预测死亡率在非吸烟者以及吸烟者。作为客观可测量的参数，可替宁更适合用于风险预测。(C)© 2014 Elsevier B. V.保留所有权利。
Background: Cotinine is one of the major metabolites of nicotine. The aim our study was to investigate cotinine as a marker for individual risk prediction in the Ludwigshafen Risk and Cardiovascular Health study.Methods: 840 samples had detectable cotinine measured using a radioimmunoassay (RIA nicotine metabolite, DPC Biermann GmbH). The distribution of risk factors across quartiles of cotinine or pack-years was analyzed by ANOVA and the association of cotinine and pack-years with mortality by Cox regression.Results: Cotinine and pack-years both showed significant association with mortality in adjusted models with HRs (95% CI) of 1.30 (1.17-1.44) and 1.26 (1.13-1.42) comparing the third to the first tertile for cotinine and pack-years, respectively. Either cotinine or pack-years or self-reported smoking increased the area-under-the-curve significantly as compared to a basic model including other risk factors.Discussion: Cotinine is a strong predictor of mortality in non-smokers as well as in smokers. As objectively measurable parameter cotinine would be preferable for risk prediction. (C) 2014 Elsevier B.V. All rights reserved.