Perinatal exposure to the estrogenic pollutant Bisphenol A affects behavior in male and female rats
Perinatal exposure to the estrogenic pollutant Bisphenol A affects behavior in male and female rats
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DOI：
10.1016/s0091-3057(99)00136-7
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发表时间：
1999-12-01
影响因子：
3.6
通讯作者：
Dessì-Fulgheri, F
中科院分区：
文献类型：
--
作者：
Farabollini, F;Porrini, S;Dessì-Fulgheri, F
双酚A（BPA）是一种环境雌激素，对公众健康有潜在的负面影响。在大鼠中，我们研究了围产期暴露于BPA对部分受性腺激素影响的非社会行为的影响。从交配前10天至幼鼠断奶，对一组母鼠口服BPA，浓度在人类暴露范围内。在第二组中，BPA在大脑组织的关键时期以更高的剂量给予，即，从妊娠第14天到出生后第6天。在85日龄时，在洞板和高架十字迷宫中测试经处理的母亲的后代。非社会行为的各个方面都受到BPA的影响，男性和女性的影响不同，这证实在大脑性别分化时期暴露于弱环境雌激素可以影响成年行为。然而，与我们的预期相反，没有观察到明显的女性男性化。在一般情况下，因素分析表明，在治疗男性的动机，探索和焦虑减少，而在女性中，运动活动和动机，探索抑郁。由于BPA给药的两种方式之间没有实质性差异，我们建议在较短的类固醇敏感期内，低剂量的长期治疗可以补偿较高剂量的治疗。鉴于人类长期接触释放到环境中的低浓度物质的发生率更高，这可能会引起公众健康方面的关注。(C)1999 Elsevier Science Inc.
Bisphenol A (BPA) is an environmental estrogen with potentially aversive effects on public health. In rats, we studied the effects of perinatal exposure to BPA on nonsocial behaviors partly influenced by gonadal hormones. BPA was administered orally to one group of mother rats at a concentration within the range of human exposure from 10 days before mating until the weaning of the pups. In a second group, BPA was given at a higher dosage during a critical period for brain organization, i.e., from day 14 of gestation until day 6 after birth. The offspring of the treated mothers were tested in the holeboard and the elevated plus-maze at 85 days of age. Various aspects of nonsocial behavior were affected by BPA, differently in males and females, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior. However, contrary to our expectation, a clear masculinization of females was not observed. In general, the factor analysis indicated that in treated males both the motivation to explore and anxiety are reduced, while in females, motor activity and motivation to explore are depressed. Because there were no substantial differences between the two modalities of BPA administration, we suggest that the prolonged treatment with the low dosage compensates for the higher dosage given during a shorter steroid-sensitive period. This may be a cause of concern for public health, given the greater incidence of prolonged exposure of humans to low concentrations released into the environment. (C) 1999 Elsevier Science Inc.