Determination of Ranitidine and Salbutamol by Flow Injection Analysis with Chemiluminescence Detection
Determination of Ranitidine and Salbutamol by Flow Injection Analysis with Chemiluminescence Detection
复制标题
流动注射化学发光检测法测定雷尼替丁和沙丁胺醇
DOI：
10.1016/s0003-2670(98)00751-x
复制
发表时间：
1999
影响因子：
6.2
通讯作者：
S. Lewis
中科院分区：
文献类型：
--
作者：
N. W. Barnett;B. Hindson;S. Lewis
基于雷尼替丁和沙丁胺醇分别与三（2，2 ′-联吡啶）钌（III）和酸性高锰酸钾的化学发光反应，建立了测定雷尼替丁和沙丁胺醇的流动注射分析方法。虽然雷尼替丁的双对数校准函数显示出显著的非线性，但精密度（以相对标准偏差测量）为1.7%（n=6 1×10− 5 M），检测限（3σ空白）为6×10− 7 M。得到了沙丁胺醇的线性对数-对数校准函数，精密度为2.7%（n=6; 1×10 - 7 M），检测限（信噪比=3）为2.5×10 - 8 M。
Flow injection analysis methodology is reported for the determination of ranitidine and salbutamol (in pharmaceutical formulations) based on their chemiluminescent reactions with tris(2,2′-bipyridyl)ruthenium(III) and acidic potassium permanganate, respectively. While the log–log calibration function for ranitidine showed significant non linearity, the precision (measured as relative standard deviation) was 1.7% (n=6 1×10−5M) and the detection limit (3σ blank) was 6×10−7M. A linear log–log calibration function was obtained for salbutamol, the precision being 2.7% (n=6; 1×10−7M) with a detection limit (signal to noise ratio=3) of 2.5×10−8M.