Pharmacokinetics and tissue penetration of enoxacin
Pharmacokinetics and tissue penetration of enoxacin
复制标题
依诺沙星的药代动力学和组织渗透性
DOI：
10.1128/aac.26.1.17
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发表时间：
1984
影响因子：
4.9
通讯作者：
M. Webberly
中科院分区：
文献类型：
--
作者：
R. Wise;R. Lockley;J. Dent;M. Webberly
研究了6名男性志愿者口服600 mg喹诺酮依诺沙星后的药代动力学。在血清、水疱液和尿液中测量化合物的水平。吸收是可变的，峰值水平（平均值，3.7微克/毫升）之间达到0.75和3.0小时（平均值，1.9小时）。血清消除半衰期为6.2 h，48 h时尿液中药物回收率为71.6%。依诺沙星对水疱液的渗透性良好，平均渗透率为78.4%。
The pharmacokinetics of the quinolone enoxacin were studied after a 600-mg oral dose was given to each of six male volunteers. The levels of the compound were measured in serum, blister fluid, and urine. Absorption was variable, with peak levels (mean, 3.7 micrograms/ml) being attained between 0.75 and 3.0 h (mean, 1.9 h). The serum elimination half-life was 6.2 h, and 71.6% of the drug was recovered in the urine by 48 h. Enoxacin penetrated blister fluid well, the mean percent penetration being 78.4%.