Sensory inputs control the integration of neurogliaform interneurons into cortical circuits.
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits.
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DOI：
10.1038/nn.3946
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发表时间：
2015-03
影响因子：
25
通讯作者：
Karayannis T
中科院分区：
文献类型：
--
作者：
De Marco García NV;Priya R;Tuncdemir SN;Fishell G;Karayannis T
哺乳动物皮层表层的神经元微电路为皮层联想计算提供了基础。抑制性中间神经元构成了电路的重要组成部分，是整合本地和远程信息的基础。在这里，我们报告说，在早期的发展，表面定位的Reelin表达神经胶质样中间神经元在小鼠体感皮层接受传入神经支配皮质和丘脑兴奋性来源。上行感觉衰减，但不是皮质内，兴奋导致这些中间神经元的轴-树突形态缺陷。此外，废除的NMDA受体，通过丘脑输入信号的结果在一个类似的表型，以及在丘脑的选择性损失和伴随的皮质内连接的增加。这些结果表明，丘脑的输入是至关重要的，在确定本地和远程连接之间的平衡，是根本的Reelin表达的中间神经元到新生的皮层电路的适当整合。
Neuronal microcircuits in the superficial layers of the mammalian cortex provide the substrate for associative cortical computation. Inhibitory interneurons constitute an essential component of the circuitry and are fundamental to the integration of local and long-range information. Here we report that, during early development, superficially positioned Reelin-expressing neurogliaform interneurons in the mouse somatosensory cortex receive afferent innervation from both cortical and thalamic excitatory sources. Attenuation of ascending sensory, but not intracortical, excitation leads to axo-dendritic morphological defects in these interneurons. Moreover, abrogation of the NMDA receptors through which the thalamic inputs signal results in a similar phenotype, as well as in the selective loss of thalamic and a concomitant increase in intracortical connectivity. These results suggest that thalamic inputs are critical in determining the balance between local and long-range connectivity and are fundamental to the proper integration of Reelin-expressing interneurons into nascent cortical circuits.