Regional changes in adrenergic receptor status during hypocaloric intake do not predict changes in adipocyte size or body shape.
Regional changes in adrenergic receptor status during hypocaloric intake do not predict changes in adipocyte size or body shape.
复制标题
低热量摄入期间肾上腺素能受体状态的区域变化并不能预测脂肪细胞大小或体形的变化。
DOI：
10.1016/0026-0495(90)90052-e
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hirsch,J
中科院分区：
文献类型：
--
作者：
Presta,E;Leibel,RL;Hirsch,J
脂肪的解剖分布与肥胖相关疾病的风险有关。在相对肥胖程度相同的个体中，那些上半身脂肪分布占优势的人（android）比那些脂肪组织优先沉积在身体下部（臀部，大腿，臀部;女性）的人有更高的糖尿病，中风，缺血性心脏病和早期死亡率。控制脂解的肾上腺素能受体（β1→脂解;α2→抗脂解）的相对活性存在充分记录的解剖部位相关差异。我们评估了在体重维持期间（4周）（T1）和在840 kcal/d饮食下体重减轻15%后（T2），从5名男性、7名女性和6名均匀肥胖女性的臀部和腹部皮下区域通过针吸活检获得的脂肪组织小片段中α2和β1肾上腺素能受体和亚受体功能的状态变化。测量体型和脂肪细胞大小，并与这些脂肪细胞代谢的变化相关。用腰臀比（WHR）来定义这些肥胖受试者的这三种类型的脂肪区域分布：男性型= WHR >0.86;女性型= WHR ≤ 0.76;均匀型= WHR > 0.76 ≤ 0.86。三组中的任何一组的WHR均未因体重减轻而发生显著变化。虽然时间和/或解剖部位对异丙肾上腺素、去甲肾上腺素、可乐定、毛喉素和二丁酰cAMP的体外反应有显著影响，但这些与人体测量或脂肪细胞大小的个体内变化无关。因此，在长期限制热量摄入期间，从特定皮下解剖部位动员脂质似乎与所研究的肾上腺素能受体或亚受体机制的功能状态改变无关。在这些情况下，身体调节脂肪动员的确切机制仍然未知。
The anatomic distribution of fat is related to the risk for obesity-associated morbidity. Among individuals with equal degrees of relative adiposity, those with an upper-body preponderance of fat distribution (android) have higher rates of diabetes, stroke, ischemic heart disease, and early death than those with preferential deposition of adipose tissue in lower portions of the body (hips, thighs, buttocks; gynecoid. There are well-documented anatomic site-related differences in the relative activities of the adrenergic receptors (β1→ lipolysis;α2→ antilipolysis) that control lipolysis. We assessed modifications of the status ofα2- andβ1-adrenergic receptor and subreceptor function in small fragments of adipose tissue obtained by needle biopsy from the gluteal and abdominal subcutaneous regions of five android, seven gynecoid, and six uniformly obese women during a period of weight maintenance (4 weeks) (T1), and after 15% weight loss on an 840 kcal/d diet (T2). Measurements of body shape and adipocyte size were made and related to changes in the metabolism of these adipocytes. The waist-to-hip ratio (WHR) was used to define these three types of regional distribution of fat in these obese subjects: android = WHR >0.86; gynecoid = WHR ≤ 0.76; uniform = WHR > 0.76 ≤ 0.86. WHR was not significantly altered by weight loss in any of the three groups. Although significant effects of time and/or anatomic site onin vitroresponses to isoproterenol, norepinephrine, clonidine, forskolin, and dibutyryl cAMP were found, these did not correlate with intra-individual changes in anthropometry or adipocyte size. Thus, the mobilization of lipid from specific subcutaneous anatomic sites during long-term restriction of caloric intake does not appear to be related to alterations in the functional status of the adrenergic receptor or subreceptor mechanisms studied. The precise mechanisms by which the body regulates fat mobilization under these circumstances remain unknown.