Oxygen saturation monitoring in experimental surgery: a comparison of pulse oximetry and arterial blood gas measurement.
Oxygen saturation monitoring in experimental surgery: a comparison of pulse oximetry and arterial blood gas measurement.
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实验手术中的氧饱和度监测：脉搏血氧测定法和动脉血气测量法的比较。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
P. Black
中科院分区：
文献类型：
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作者：
J. Vender;C. Hand;D. Sedor;S. L. Tabor;P. Black
动物模型中的实验性手术通常需要长时间的全身麻醉。接受这些手术的动物可能难以维持正常通气和氧合，因此可能需要进行生理监测和气管插管，以避免缺氧，这可能对研究结果产生不利影响。监测传统上包括PaO 2、PCO 2、pH和从动脉血计算的氧饱和度的测量。术中采集标本进行血气分析所需的气管插管和动脉导管放置是劳动密集型和耗时的。在本研究中，通过无创脉搏血氧测定法监测接受胸椎板切除术（作为脊髓损伤研究的一部分）的大鼠，将反射传感器放置在颈部皮肤/皮毛上，覆盖颈部颈动脉。将这些数据与相同动物的间歇性动脉血气测量值进行比较，表明与脉搏血氧测定值的一致性> 90%。我们还确定了吸入氧气（FiO 2）的分数，通过面罩输送，可以达到至少90%的最低正常氧饱和度（SaO 2）。这些研究结果表明，在实验啮齿动物手术期间的生理监测可以大大简化脉搏血氧饱和度和通过面罩输送氧气，消除了对动脉血气测定或气管插管的需要。
Experimental surgery in animal models often requires prolonged periods of general anesthesia. Animals undergoing these procedures may have difficulty maintaining normal ventilation and oxygenation and therefore may require physiologic monitoring and endotracheal intubation to avoid hypoxia that could adversely affect the results of the investigation. Monitoring has traditionally included measurements of PaO2, PCO2, pH, and oxygen saturation calculated from arterial blood. Endotracheal intubation and placement of arterial catheters necessary for the intraoperative collection of specimens for blood gas analysis are labor-intensive and time-consuming. In this study, rats undergoing thoracic laminectomy as part of a study on spinal cord injury were monitored by noninvasive pulse oximetry, with a reflectance transducer placed on the skin/fur of the neck overlying the cervical carotid artery. Comparison of these data with intermittent arterial blood gas measurements in the same animals indicated > 90% concordance with the pulse oximetry values. We also determined the fraction of inspired oxygen (FiO2) that, delivered via facemask, can achieve at least the minimal normal oxygen saturation (SaO2) of 90%. These findings suggest that physiologic monitoring during experimental rodent surgery can be substantially simplified by pulse oximetry and by delivery of oxygen via facemask, eliminating the need for arterial blood gas determinations or endotracheal intubation.