CENTRAL NORADRENERGIC REACTIVITY TO STRESS IN MAUDSLEY RAT STRAINS
CENTRAL NORADRENERGIC REACTIVITY TO STRESS IN MAUDSLEY RAT STRAINS
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DOI：
10.1016/0304-3940(94)91021-9
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发表时间：
1994-02-14
影响因子：
2.5
通讯作者：
SARA, SJ
中科院分区：
文献类型：
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作者：
BUDA, M;LACHUER, J;SARA, SJ
Maudsley反应性（MR）和Maudsley非反应性（MNRA）大鼠提交了一个单一的会议的急性5分钟制动应力，并立即处死断头。随后的神经化学分析显示，与非应激对照组相比，两种品系大鼠的蓝斑和延髓腹外侧区的3，4-二羟基苯乙酸水平升高，但延髓背内侧区的水平没有升高;这种反应在MR中比在MNRA组中更大，表明中枢去甲肾上腺素能细胞对急性应激的反应性存在品系差异。
Maudsley reactive (MR) and Maudsley nonreactive (MNRA) rats were submitted to a single session of acute 5-min immobilization stress and immediately sacrificed by decapitation. Subsequent neurochemical analysis revealed an elevation of 3,4-dihydroxyphenylacetic acid levels in the locus coeruleus and in the ventrolateral medulla, but not in the dorsomedial medulla, of rats of the two strains compared with nonstressed controls; This response was greater in the MR than in the MNRA group, suggesting a strain difference in the reactivity of the central noradrenergic cells to acute stress.