Higher order response adaptive urn designs for clinical trials with highly successful treatments.
Higher order response adaptive urn designs for clinical trials with highly successful treatments.
复制标题
高阶响应自适应瓮设计，用于治疗非常成功的临床试验。
DOI：
10.1111/rssc.12066
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hoberman,Steven
中科院分区：
文献类型：
--
作者：
Ivanova,Anastasia;Hoberman,Steven
We consider a problem of reducing the expected number of treatment failures in trials where the probability of response to treatment is close to 1 and treatments are compared on the basis of the log-odds ratio. We propose a new class of urn designs for randomization of patients in a clinical trial. The new urn designs target a number of allocation proportions including the allocation proportion that yields the same power as equal allocation but significantly less expected treatment failures. The new design is compared with the doubly adaptive biased coin design, the efficient randomized adaptive design and with equal allocation. The properties of the new class of designs are studied by embedding them in a family of continuous time stochastic processes.
