Comparison of 2-octyl cyanoacrylate adhesive, fibrin glue, and suturing for wound closure in the porcine urinary tract
Comparison of 2-octyl cyanoacrylate adhesive, fibrin glue, and suturing for wound closure in the porcine urinary tract
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DOI：
10.1016/s0090-4295(00)01075-x
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发表时间：
2001-04-01
期刊：
影响因子：
2.1
通讯作者：
Wolf, JS
中科院分区：
文献类型：
--
作者：
Marcovich, R;Williams, AL;Wolf, JS
目标。目的评价氰基丙烯酸异辛酯胶(OCG)封闭尿路伤口的效果，并比较OCG、纤维蛋白胶(FC)和缝合线抗生理和生理应激的能力，因为使用OCG或FG等组织粘合剂可以简化腹腔镜手术。雌性家猪(n=22)接受7.5 cm长的膀胱切开术。其中OCG闭合8例，FG闭合8例(开放手术6例，腹腔镜术2例)。对照组4例缝合，2例不缝合。术后未使用导尿管引流。术后2天或4周，膀胱内注入生理盐水至200 mm Hg压力，检查膀胱术后瘢痕有无渗漏。切除的瘢痕还进行了组织学检查。术后第2天测试的2头OCG和2头FG猪的漏气量均小于200毫米汞。4周龄的6头OCG猪无一例漏出低于200毫米汞柱的气体，包括2头闭合的腹腔镜猪。4周龄拟研究的6头FC猪中，3头死于大量尿漏，1头4周龄检测漏尿，2头未漏尿。因此，4周后，OCG组6头FG猪中有4头发生渗漏(P=0.06)。两组的组织学检查结果相似。初步结果表明，OCG提供了足够的力量来固定一个大的膀胱伤口。在同一模型中，FG没有始终如一地提供足够的闭合。泌尿外科57：806-810,2001。(C)2001年，爱思唯尔科学公司。
Objectives. To evaluate 2-octyl cyanoacrylate glue (OCG) for wound closure in the urinary tract and compare the ability of OCG, fibrin glue (FC), and suture to withstand physiologic and supraphysiologic stress, because the use of tissue adhesives such as OCG or FG might simplify laparoscopic surgery.Methods. Female domestic pigs (n = 22) underwent a 7.5-cm cystotomy. Of these, 8 had closure with OCG and 8 with FG (6 open and 2 laparoscopic in each group). The controls were closed with suture (n = 4) or not at all (n = 2). Postoperative catheter drainage was not used. At 2 days or 4 weeks postoperatively, the bladders were filled with saline to 200 mm Hg pressure and the cystotomy scars inspected for leakage. The excised scars were also examined histologically.Results. The 2 OCG and 2 FG pigs tested on postoperative day 2 leaked at less than 200 mm Hg. None of the 6 OCG pigs tested at 4 weeks leaked at less than 200 mm Hg, including the 2 closed laparoscopically. Of the 6 FC pigs intended for study at 4 weeks, 3 (including the 2 closed laparoscopically) died from a massive urine leak, 1 tested at 4 weeks leaked, and 2 did not leak. Thus, 4 of 6 FG pigs leaked by 4 weeks compared with none in the OCG group (P = 0.06). The histologic examination was similar in the two groups.Conclusions. Preliminary results suggest that OCG provides enough strength to hold together a large bladder wound. In the same model, FG did not consistently provide adequate closure. UROLOGY 57: 806-810, 2001. (C) 2001, Elsevier Science Inc.