Transient receptor potential A1 modulators.
Transient receptor potential A1 modulators.
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DOI：
10.2174/156802611796904915
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发表时间：
2011-08
影响因子：
3.4
通讯作者：
T. Strassmaier;R. Bakthavatchalam
中科院分区：
文献类型：
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作者：
T. Strassmaier;R. Bakthavatchalam
TRPA1是一个非选择性阳离子通道超家族的成员，已知参与多种生理功能。TRPA1被广泛的化学刺激物和内源性炎症化合物激活。TRPA1在介导疼痛和炎症中的新作用提高了靶向TRPA1的化合物可能具有重大治疗潜力的可能性。本文讨论了已知的TRPA1激动剂和拮抗剂的广泛分子类别，旨在概述TRPA1调节剂的结构和活性。
TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.